车前子对高脂血症大鼠脂质过氧化的影响  

EFFECT OF PLANTAGO ASIATICA L.SEED ON THE ANTIOXIDATION IN RATS

作　　者：王素敏[1] 张杰[1] 李兴琴[1] 朱树森[1] 

机构地区：[1]河北省医学科学院生化研究室,石家庄050021

出　　处：《营养学报》2003年第2期212-214,共3页Acta Nutrimenta Sinica

基　　金：河北省科技厅基金(N o.992 76 2 14 D)

摘　　要：目的 :　探讨车前子对高脂血症大鼠脂质过氧化的影响。方法 :　采用大鼠血清及多脏器组织 ,观察车前子对高脂血症大鼠脂质过氧化的影响。结果 :　高脂对照组血清和心肌超氧化物歧化酶 ( SOD)活性显著降低 ,而脂质过氧化物 ( LPO)含量明显升高 ,血清和肝脏的过氧化氢酶( CAT)、谷胱苷肽过氧化物酶 ( GSH-Px)活性明显降低。补充车前子后显著升高血清及心肌组织SOD活性 2 2 %和 2 8% ,以及肝脏 GSH-Px活性 2 2 %。而使血清及心肌的 LPO含量分别下降 3 2 %和 1 7%。结论 :　 1 5Objective: To investigate the effect of Plantago asiatica L. on antioxidation in rats. Methods: The antioxidative enzymes and LPO of serum, heart, and liver tissues were determined. Results: The activities of superoxide (SOD) in serum and heart were significantly lower than that of the control. The lipid peroxide (LPO) level in serum and heart was markedly higher than that of the control. Serum and liver catalase (CAT) activities in rats fed with high fat were decreased. Activities of liver glutathione peroxidase (GSH Px) in high fat rats were decreased significantly. The production of SOD activities in serum and liver and GSH Px in liver were increased significantly in rats maintained on Plantago asiatica L. supplemented diets, meanwhile serum and heart LPO were reduced. Conclusion: 15g/kg Plantago asiatica L. can increase the antioxidation against lipid peroxide in hyperlipidemic rats.

关 键 词：高脂血症 车前子 脂质过氧化 超氧化物歧化酶 过氧化氢酶 

分 类 号：R285.5[医药卫生—中药学]