TGF-β诱导CTGF表达的信号转导途径及与纤维化形成  

Signaling events required for TGF-β stimulation of CTGF expression and their role in fibrosis formation

作　　者：赵青[1] 陈楠[1] 周同[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025

出　　处：《生命科学》2003年第3期155-158,共4页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金(30270613);上海市卫生局医学专业领先学科基金(983009)

摘　　要：转化生长因子—β(transforming growth factor-β,TGF-β)是一种具有多重生物学效应的细胞因子,参与了多种组织器官纤维化的形成。结缔组织生长因子(connective tissue growth factor,CTGF)是一种富含半胱氨酸的多肽,是介导TGF-β致纤维化作用的重要下游因子之一。TGF—β可通过多种信号途径诱导CTGF表达,本文就这一领域的研究进展及与纤维化形成的关系做一简要综述。Transforming growth factor-β(TGF-β) is a pleiotropic cytokine that involves in the regulation of many fibrotic disorders. Connective tissue growth factor (CTGF) is a cysteine-rich peptide and one of the critical mediator in many of the important fibroproliferative effects of TGF-β. TGF-β induction of CTGF expression is mediated through several signaling pathways. Present paper reviewed the recent studies of signaling events required for TGF-β stimulation of CTGF expression and their role in fibrosis formation.

关 键 词：转化生长因子-Β 结缔组织生长因子 信号转导 纤维化 

分 类 号：Q25[生物学—细胞生物学]