胸腺肽α1对慢性乙型肝炎患者免疫系统的影响  

Effect of thymosin-α1 on immune function with chronic hepatitis B

作　　者：段国荣[1] 聂青和[2] 周永兴[2] 王全楚[2] 田长印[3] 刘拉羊[3] 薛红安[3] 

机构地区：[1]西安市中心医院感染科,陕西省西安市710003 [2]中国人民解放军第四军医大学唐都医院全军感染病诊疗中心,陕西省西安市710038 [3]西安交通大学第二医院感染病科,陕西省西安市710004

出　　处：《世界华人消化杂志》2003年第6期701-704,共4页World Chinese Journal of Digestology

摘　　要：目的:了解胸腺肽α 1(Tα1)对慢性乙型肝炎患者免疫系统的影响,评价Tα1对慢性乙型病毒性肝炎的疗效。方法:选择60例慢性乙型肝炎患者,其中Tα1组25例,给予Tα1(1.6mg,sc,2次/wk,3-6 mo)治疗,联合组35例,给予Tα1联合贺普丁(0.1g,po,1次/d,3-6 mo)治疗,另选60例作为对照组,仅给予保肝治疗。应用双抗体酶联分析法检测治疗前后血清中IFN-γ和IL-4的浓度,以IFN-γ代表Th1,IL-4代表Th2,从而计算Th1/Th2比值;采用流式细胞仪观察外周血CD_4^+T,CD_s^+T细胞亚群。结果:联合组与对照组比,治疗后肝功能改善显著(P<0.01);联合组乙型肝炎病毒标志物HBsAg或HBeAg阴转(9例)及HBV-DNA定量指标降低(14例),与对照组比,均具有统计学差异(P<0.01;P<0.05).但Tα1组分别与对照组、联合组比,无统计学差异(P>0.05)。Tα1组治疗后CD_4^+T细胞增高(由31.3±2.4增高到36.1±2.5)具有统计学意义(P<0.01),CD_8^+T细胞稍高且CD4^+/CD8^+无明显变化,相差无统计学意义(P>0.05);IFN-γ浓度(由71.3±21.0增高到83.7±21.4)及Th1/Th2比值升高(由0.79±0.2增高到0.98±0.3)均有统计学意义(P均<0.05),但IL-4表达水平变化无统计学意义。结论:Tα1能提高机体的细胞免疫功能,有利于病毒清除和疾病的恢复。AIM: To realize effect of thymosin-α1 (Tα1) on immune function with chronic hepatitis B(CHB) and to evaluate the efficacy of Tα1 in the treatment of CHB. METHODS: Sixty patients with CHB were randomly chosen. Twenty-five cases were received Tα1 (1.6mg, sc, twice a week, 3-6mo) and thirty-five were received Tα1 combined with Lamivudine (0.1g, po, once a day, 3-6 mo). Hepatic function, virological analyses (HBeAg, HBsAg, HBV-DNA) and immunological analyses (periperal blood T lymphocytes subset, IFN-α and IL-4 levels) from patients in pretreatment and posttreatment were observed. RESULTS: At the end of treatment, ALT and T-Bil were decreased in the group of Tαl combined with Lamivudine(P<0.01), HBeAg/HBsAg remained negative (n=9) and HBV-DNA levels were also low (n=14) in the group of Tα1 combined with Lamivudine (P<0.01 and P<0.05, respectively) as compared with healthy individuals. CD_4^+ T Cell (from 31.3±2.4 to 36.1±2.5), the level of IFN-γ(from 71.3±21.0 to 83.7±21.4) and Th1/Th2 (from 0.79±0.2 to 0.98±0.3) increased in the group of Tα1 (P<0.01, P<0.05 and P<0.05, respectively). CONCLUSION: Tα1 is efficient to treat patients with CHB because it can elevate the level of cellular immunity, which is beneficial to viral clearance.

关 键 词：胸腺肽Α1 免疫系统 疗效 慢性乙型病毒性肝炎 检测 血清 IL-4 IFN-Γ 

分 类 号：R512.62[医药卫生—内科学]