川芎嗪对麻醉兔的血流动力学影响  

Effect of Tetramethylpyrazine on Hemodynamics in Anesthetized Rabbits

作　　者：阮琴[1] 胡燕月[1] 何新霞[1] 徐庆 余春珠[1] 

机构地区：[1]浙江师范大学生命与环境科学学院，浙江金华321004 [2]浙江金华医学院，浙江金华321000

出　　处：《绍兴文理学院学报（自然科学版）》2003年第8期19-21,共3页Journal of Shaoxing College of Arts and Sciences

基　　金：浙江省教育厅资助项目，浙江师范大学校科研和教改项目

摘　　要：目的：观察川芎嗪（TMP）对麻醉兔的急性血流动力学的影响。方法：麻醉兔静脉流向盐酸川芎嗪（TMPM）和生理盐水（NS）。结果：注射TMPM组快速显著增加左心室收缩压（LVSP）、左心室压上升最大速率（+LVdp/dtmax）、左心室压下降最大速率（-LVdp/dtmax）和缓慢降低心率（HR），注射NS组以上各血流动力学参数无明显变化，两组差异显著。结论：TMP具有明显的血流动力学效应。AIM: To observe the effect of tetramethylpyrazine (TMP) on hemodynamics in anesthetized rabbits. METHODS: TMPM and normal saline (NS) were separately injected into the anesthetized rabbits. RESULTS: The group which were injected TMPM quickly and evidently increased left ventricular systolic pressure (LVSP) , peak positive first derivative of left ventricular ( + LVdp/dtmax) and peak negative first derivative of left ventricular ( - LVdp/ dtmax), and decreased heart rate (HR) slowly, but the group which were injected NS did not produce any significant hemodynamic changes. There were apparent difference between the two groups. CONCLUSION: TMP has the obvious effect on hemodynamics.

关 键 词：川芎嗪 麻醉兔 血流动力学 生理盐水 中药 药物效应 左心室收缩压 左心室压上升最大速率 

分 类 号：R285.5[医药卫生—中药学] R318.01[医药卫生—中医学]