Cathelicidins抗菌肽家族的研究进展  

Advance in Cathelicidins Antimicrobial Peptides

作　　者：金飞燕[1] 王旻[1] 陈代杰[2] 

机构地区：[1]中国药科大学生物制药学院,南京210009 [2]上海来益生物药物研究开发中心,上海201203

出　　处：《药物生物技术》2003年第3期186-190,共5页Pharmaceutical Biotechnology

摘　　要：Cathelicidins是一族在哺乳动物中发现的含有保守的cathelin区域的抗菌肽 ,是宿主防御系统的重要组成部分 ,具有广谱且强大的抗菌活性。文章综述了cathelicidins抗菌肽家族的基因组成、结构、抗菌活性。Cathelicidins, a family of mammalian antimicrobial peptides that carry a highly conserved cathelin domain, are important components of host defense immunity system. They exert a broad spectrum and potent antimicrobial activities. This review is aimed at providing a general overview of cathelicidins , with emphasis on aspects such as biosynthesis genes ,structural features ,antimicrobial spectrum , mechanism of action and structure/activity relationship studies.

关 键 词：CATHELICIDINS 抗菌肽 抗菌活性 

分 类 号：Q514.3[生物学—生物化学]