初诊糖尿病患者使用ACEI干预血压对肾脏的影响  

Effect of Blood Pressure Interfered by ACEI on Kidney in Early Diabetes Mellitus

作　　者：雍军光 阮萍[2] 

机构地区：[1]桂林市第二人民医院内分泌科,广西桂林541001 [2]桂林医学院药学院,广西桂林541004

出　　处：《华夏医学》2003年第3期294-295,共2页Acta Medicinae Sinica

基　　金：广西科学基金资助项目 ( No.0 2 3 60 67)

摘　　要：目的 :探讨早期糖尿病患者予 ACEI干预血压后对肾脏的影响。方法 :符合 1997年美国 ADA糖尿病的诊断标准诊断为糖尿病者予 ACEI类药物口服 ,从小剂量开始 ,使血压控制≤ 17.3/ 10 .7k Pa,并测定血尿 β2 微球蛋白、血脂、空腹胰岛素、体重指数、空腹加餐后 2 h血糖、Hb A1 c。结果 :初诊糖尿病患者早期控制血压 ,使血压控制≤ 17.3/ 10 .7k Pa,对肾脏的影响最小 ,可保护肾脏功能 ,减少尿蛋白的排泄 ,延缓糖尿病患者慢性并发症的发生。结论 :ACEI特别适合糖尿病伴或不伴高血压患者的治疗 。Objective:To explore the effect of blood pressure interfered by ACEI on Kidney in early diabetes mellitus.Metheds:Patients,who were diagnosed by the diagnosis standard of ADA (USA,1997),were administered ACEI orally.The dose of ACEI was regulated to control the blood pressure at about 17.3/10.7kPa.The β 2 microglobulin in blood and urine,blood lipid,fasting insulin,body mass index,blood glucose after diet and HbA 1c were detected.Results:Early control of blood pressure (at range of 17.3/10.7kPa) may protect the function of kidney and reduce the excretion of protein in urine as well as delay the development of chronic complications in diabetes mellitus.Conclusion:ACEI treatment is specially suitable for the patients of diabetes mellitus with or without hypertension.It can be used ordinarily in clinical practice.

关 键 词：ACEI 糖尿病 血压 肾脏 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]