发作性睡眠治疗药莫达非尼的合成  

Synthesis of the Modifinil

作　　者：王巧玲[1] 刘智凌[2] 卢其慧 廖文文[2] 王晓光[2] 

机构地区：[1]长沙环境保护职业技术学院,长沙410000 [2]湖南化工研究院,长沙410007 [3]深圳科达科药物科技有限公司,深圳518115

出　　处：《精细化工中间体》2003年第3期26-27,共2页Fine Chemical Intermediates

摘　　要：以二苯甲酮为原料 ,经催化合成二苯甲醇 ,再与 2 巯基乙酸反应合成 2 二苯甲基硫代乙酸 ,再经SOCl2 氯化 ,氨水氨化和H2 O2 氧化合成产品莫达非尼 ,熔点 1 64～ 1 65 5℃ ,含量 99% ,总收率 66 8%。The modifinil was synthesized from benzophenone as material. As first, the benzophenone was reduced to benzhydrol, then, which reacted with 2 thioglycollic acid to produce 2 diphenyl methylthioacetic acid, which was chloriated by SOCl 2, aminated by ammonia and then exidized by H 2O 2. The melt point of the product is 164～165?℃, Content 99%, and the overall yield 66.8%.

关 键 词：莫达非尼 二苯甲酮 二苯甲醇 

分 类 号：TQ225.26[化学工程—有机化工]