左旋氧氟沙星乳膏的制备与质量控制  

Preparation and Quality Control of Levofloxacin Cream

作　　者：陈涌江[1] 梁毅 梁厚权 杨金玲 张振家 张雷 

机构地区：[1]中国人民解放军第465医院药剂科 [2]中国人民解放军第95439部队卫生队

出　　处：《解放军药学学报》2003年第3期197-199,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　制备左旋氧氟沙星乳膏 ,建立质量控制方法。方法　以左旋氧氟沙星为主药 ,地塞米松磷酸钠为辅药 ,乳膏基质 4号为赋形剂 ,制备左旋氧氟沙星乳膏。用紫外分光光度计在 2 94nm处测定左旋氧氟沙星的含量 ,建立质量控制方法。结果　其线性范围为 3.2～ 7.2 μg·ml-1,平均回收率为 97.3% ,RSD为 2 .3%。结论　制备方法和质量控制方法简便、快捷。Aim To prepare levofloxacin cream and establish its quality control.Methods Using cremoris basis No.4 as the excipients and desamethasone sodium phosphate as asassistant drug,levofloxacin cream was prepared.The quality control of levofloxacin cream was established.The content of the ingredent,levofloxacin was determined by uv spectrphotoment at wavelength of 294nm.Results The linear range was 3.2～7.2μg·ml -1 ,the average recovery is 97.3% with RSD of 2.3%.Conclusion The prepaation and quality control is simple,quick and accurate.

关 键 词：左旋氧氟沙星乳膏 制备 质量控制 地塞米松磷酸钠 含量测定 

分 类 号：R978.1[医药卫生—药品]