涂碳式聚氯乙烯膜双嘧达莫选择电极的研制与应用  

Preparation and application of coated carbon PVC membrane-dipyridamole selective electrode

作　　者：李东辉[1] 丁扬栋[1] 汪敏[1] 蔡东[2] 何晓东[2] 

机构地区：[1]锦州医学院,辽宁锦州121001 [2]沈阳信息技术研究中心,辽宁沈阳110001

出　　处：《沈阳药科大学学报》2003年第4期280-281,287,共3页Journal of Shenyang Pharmaceutical University

摘　　要：目的建立用涂碳式聚氯乙烯膜双嘧达莫电极测定双嘧达莫片含量的方法。方法利用该电极对双嘧达莫的响应 ,测定双嘧达莫片含量。结果平均回收率为 98 6 % ,RSD≤ 4 37% ,响应范围为 4 2× 10 -3 ～ 3 0× 10 -5mol·L-1,检测限为 1 7× 10 -5mol·L-1。结论涂碳式聚氯乙烯膜电极法可简便、快速、准确地检测片剂中双嘧达莫的含量。Objective To establish an accurate method to determine dipyridamole by coated carbon PVC membrane selective electrode.Methods The electrode showed the Nernst response for dipyridamole.Dipyridamole can be quantitatively determined.Results The average recovery was 98 6% and RSD≤4 37%.The Nernst response range between 4 2×10 -3 to 3 0×10 -5 mol·L -1 with a slope of 30 mV/pC ,the detection limit is 1 7× 10 -5 mol·L -1 .Conclusions The method can be used to determine the concentration of dipyridamole in tablets simply,rapidly and accurately.

关 键 词：离子选择电极 涂碳 双嘧达莫 测定 

分 类 号：R917[医药卫生—药物分析学] O657.15[医药卫生—药学]