慢性肺心病患者血1,25-(OH)_2D_3与钙磷镁代谢  

Study on serum 1,25-(OH)_2D_3 and metabo1ism of calcium? phosphorus?magnesim in patients with advanced cor pulmonale

作　　者：王方剑 王春丽[2] 王昶[3] 杨劲松[2] 黄强[2] 

机构地区：[1]解放军第464医院呼吸内科,天津300381 [2]第四军医大学吉林军医学院附属解放军第465医院呼吸内科 [3]吉林市中心医院

出　　处：《天津医科大学学报》2003年第2期267-269,共3页Journal of Tianjin Medical University

摘　　要：目的 :探讨1,25 -(OH)2D3 水平改变在慢性肺心病患者钙、磷、镁代谢紊乱中的作用。方法 :测定了48例该病患者血1,25 -(OH)2D3 和血、24h尿钙、磷、镁 (SCa、SP、SMg ,UCa、UP、UMg)含量及肾小管钙、磷、镁重吸收率(TRCa、TRP、TRMg)。结果 :1,25 -(OH)2D3 患者组显著低于对照组 ;SCa、SMg患者组显著低于对照组 ,SP患者组与对照组比较无显著降低 ;患者组UCa相对增加者占37.5 % ,UMg 相对或绝对增加者占75.0 % ;TRCa相对或绝对减少者占66.7 % ,TRP减少者占35.4 %。结论 :1,25 -(OH)2D3 降低是该病患者钙、磷。Objective: To probe the role of the change of serum 1,25-(OH)2D3 in metabolic disorder of calcium?phosphorus and magnesium in patients with advanced cor pulmonale. Methods:The serum 1,25-(OH)2D3 the serum and 24h urinary calcium?phosphorus and magnesium(SCa?SP?SMg,UCa?UP?UMg) were measured, and the reabsorption rates of renal tubular calcium?phosphorus and magnesium(TRCa? TRP? TRMg) were calculated in 48 cases with the disease. Results:The serum1,25-(OH)2D3 was lower significantly,the SCa?SMg were lower significantly,the SP were lower nonsignificantly,compared with the control group.TheUCa of 37.5%patients increased relatively, the UMg of 75.0%increased relatively or absolutely.the TRCa of 66.7% patients decreased relatively or absolutely,the TRP of 35.4% patients decreased relatively,the TRMg of all patients decreased relatively or absolutely. Conclusion:Decrease of serum 1,25-(OH)2D3 is reasons for the metabolic disorder of calcium?phosphorus and magnesium.

关 键 词：肺心病 1 25-(OH)2D3 钙 磷 镁 

分 类 号：R541.5[医药卫生—心血管疾病]