血清肌红蛋白和碳酸酐酶测定在急性心肌梗塞早期诊断中的应用  

Application of myoglubin and carbonic anhydrase in the early diagnosis of acute myocardial infarction

作　　者：张艳君[1] 李明润[2] 高向耘[2] 李明[2] 

机构地区：[1]天津医科大学生化教研室,天津300070 [2]天津医药科学研究所医用生化室

出　　处：《天津医科大学学报》2003年第2期169-170,176,共3页Journal of Tianjin Medical University

基　　金：天津市卫生局科学基金资助 (96KF12)

摘　　要：目的 :探讨同时测定血清肌红蛋白 (myoglobin,Mb)和碳酸酐酶(carbonicanhydrase,CA)在急性心肌梗塞 (AMI)诊断中的价值。方法 :用放射免疫法和比色法分别测定35例AMI、15例骨骼肌疾病和75例健康人的Mb和CA。结果 :Mb与Mb/CA在AMI诊断中的灵敏性分别为97 %和91 % ,特异性分别为70%和94 %。结论 :Mb/CA在AMI诊断灵敏性和特异性都高 。Objective: To study the value of determinating serum myoglubin and carbonic anhydrase in the early diagnosis of acute myocardial infarction.Methods:To determinate the level of serum myoglubin and carbonic anhydrase of 35 patients with AMI, 15 patients with skeletal muscle diseases and 75 healthy persons by RIA and colorimetric assay.Results:The sensitivities of myoglubin and myoglubin/myoglubin/carbonic anhydrase are 97 percent and 91 percent respectively. The specificities of myoglubin and myoglubin/carbonic anhydrase are 70 percent and 94 percent respectively. Conclusion:The ratio of myoglubin/carbonic anhydrase is sensitive and specity in detecting AMI,it is a complement index in clinical diagnosis.

关 键 词：肌红蛋白 碳酸酐酶 急性心肌梗塞 

分 类 号：R542.22[医药卫生—心血管疾病]