天津市区10所医院阴沟肠杆菌下呼吸道感染临床研究  

Clinical investigation of lower respiratory tract infection caused by enterobacter cloacae from 10 hospitals in Tianjin

作　　者：张菊英[1] 司进[1] 葛庚芝[1] 李彬[1] 

机构地区：[1]天津医科大学第二医院内科,天津300211

出　　处：《天津医科大学学报》2003年第2期237-239,共3页Journal of Tianjin Medical University

摘　　要：目的 :研究阴沟肠杆菌所致下呼吸道感染特点。方法 :回顾分析了天津市区10所医院呼吸科2000年～2002年收治的35例阴沟肠杆菌所致下呼吸道感染患者的临床表现及细菌培养结果。结果 :在天津市区10家医院呼吸科阴沟肠杆菌所致下呼吸道感染中慢性支气管炎急性发作占多数 ,其次为社区获得性肺炎、院内感染肺炎等。老年人、有慢性基础疾病、长期应用广谱抗生素、肾上腺皮质激素以及气管插管、呼吸机治疗的病人易发生阴沟肠杆菌下呼吸道感染。阴沟肠杆菌下呼吸道感染的临床表现缺乏特异性 ,药敏结果显示在测试的抗生素中阴沟肠杆菌头孢唑林耐药率最高 ,为100.0 % ;其次为氨苄西林耐药率90.9% ,亚胺培南未发现有耐药菌。结论 :临床上可首选亚胺培南治疗阴沟肠杆菌下呼吸道感染。Objective: To investigate the clinical featuress of lower respiratory tract infection caused by enterobacter cloacae.Methods: The clinical data and antibiotic susceptibility studies of 35 cases from respiration department of 10 hospitals in Tianjin during 2000～2002 were reviewed.Results: Chronic bronchitis acute attack is the most in the lower respiratory tract infection caused by enterobacter cloacae from 10 hospitals in Tianjin during 2000～2002, community-acquired pneumonia and nosocomal pulmonary infection is the next.Lower respiratory tract infection caused by enterobacter cloacae occurred mostly in the older and week patients, especially accompanied by severe underlying diseases, long term using of broad spectrum antibiotics, adrenal cortical hormone,endotracheal intubation and treated by ventilator.It's clinical features were lack of specificity.The antibiotic susceptibility studies showed the antibiotic resistance to cefozolin is highest,which is 100.0%,next is to ampicillin, which is 90.9%.There is no resistance to imipenem.Conclusion: Imipenem is the first choice to treat lower respiratory tract infection caused by enterobacter cloacae, choice of non-β-lactam antibiotics must depend on the results of antibiotic susceptibility studies.

关 键 词：下呼吸道感染 阴沟肠杆菌 抗生素 

分 类 号：R562[医药卫生—呼吸系统]