肝胆病患者血凝指标检测的临床价值  

The clinical implication of blood coagulation analysis in patient with hepatitis and cholecystitis

作　　者：赵颖[1] 李霞[1] 王立斌[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2003年第7期396-397,共2页Ningxia Medical Journal

摘　　要：目的　研究各种肝胆病患者血浆凝血酶原时间 (PT)、抗凝血酶活性 (AT)、纤维蛋白原 (FIB)、活化部分凝血酶时间 (KPTT)测定的临床价值。方法　应用美国仪器公司ACL - 2 0 0型血凝分析仪 ,检测各种肝胆病患者 3 3 3例 ;对照组选自住院单纯性骨折病人 ,且无心、肝、肾功能异常者 80例。结果　肝病中除肝包虫组各项结果与对照组相比无差异外 ,其他各组与对照组相比均有显著性差异 (P <0 .0 1或P <0 .0 0 0 1)。死亡组 4项指标与对照组相比差异在 10倍左右 ,肝破裂、肝硬化腹水组KPTT高于对照组 10倍以上 ,FIB、AT低于对照组一半以下。胆囊病血浆FIB、KPTT与对照组比较没有显著性意义 ,PT、AT与对照组比较具有显著性意义 (P <0 .0 5或P <0 .0 1)。肝胆病患者随着肝脏受损程度 ,各项指标有着明显的变化。结论　血凝 4项指标检测 ,可直接反映肝病轻重、肝功能状况、肝细胞受损程度、肝脏有无衰竭、预后评估 。Objectives To study the clinical implication of analysis PT,AT,FIB,KPTT in patient with hepatitis and cholecystitis.Methods To detected 333 cases hepatitis and clolecystitis patients,and 80 cases normal person as control.All cases were determined respectively by American Beckman-Coulter ACL-200 type Blood Coagulation Analyzer.The date was statistics by Excel-2000Microsoft.Results Compared with normal person,all group have significant difference(P<0.01 or P<0.0001) except hydrated disease of liver group.The difference in death group was up to 10 times;KPTT in Hepatorrhexis and Cirrhosis group was higher than 10 times;and FIB,AT was less than half of the normal patient;also,PT,AT in Cholecystitis patients have great significant difference (P<0.05 or P<0.01).But FIB,KPTT has negative relationship with normal person.Conclusions Detect the changes of PT,AT,FIB,and KPTT in patient with Hepatitis and Cholecystitis can reflecting the condition of liver disease and the rupture of liver,also it can provide an accuracy,reliable parameter for curative observe and the death of patients.

关 键 词：肝病 胆囊病 血凝 血浆 检测 

分 类 号：R446.11[医药卫生—诊断学]