蝮蛇抗栓酶纤维蛋白降解作用机理的体外研究  

In vitro studies on the mechanism of fibrin degradation induced by antithrombotic esterase of pit viper

作　　者：柳东田[1] 刘淑洁[1] 

机构地区：[1]佳木斯医学院第一附属医院心内科

出　　处：《佳木斯医学院学报》1992年第1期6-8,共3页

摘　　要：通过纤维蛋白—琼脂平皿法及加热纤维蛋白纤溶试验研究了蝮蛇抗栓酶纤维蛋白降解作用机理,以尿激酶作对照。结果表明:蝮蛇抗栓酶具有活化素样作用,同时还具有类纤溶酶作用,均呈剂量效应关系,且6 24×10^(-3)U与2.5U尿激酶纤溶活力相当。The mechanism of antithrombotic esterase of pit viper in the degradation of fibrin was studied by the methods of fibrin-agar plate and heating fibrin plate. Urokinase was used as the control. It was shown that antithrombotic esterase of pit viper had activator -like and plasminoid effects, and a dose-effect relationship was shown in either of them. The fibrinolytic activity of 6.25× 10^(-3)u antithrombotic esterase of pit viper was equal to that of 2.5u urokinase.

关 键 词：蝮蛇抗栓酶 尿激酶 纤维蛋白 药理 

分 类 号：R965.1[医药卫生—药理学]