甘草、白芍及合用对在体兔肠管运动的影响  

The effect of Glycyrrhiza and Paeonia extraction on the movement of intestinal smooth muscle in rabbits in vivo

作　　者：李怀荆[1] 郭忠兴[1] 陈晓光[1] 马春力[1] 赵锦程[1] 郑文涛 

机构地区：[1]佳木斯医学院药理教研室 [2]七台河市茄子河区医院

出　　处：《佳木斯医学院学报》1992年第5期10-12,共3页

摘　　要：甘草、白芍水提合剂(0.21g)对在体兔肠管平滑肌运动有明显的抑制作用,两者合用较单用效果好,降频率作用较降幅度作用强。给药后20min—25min降低兔肠管收缩频率分别为正常对照组的64.71％和70.5％,二者比较有显著性差异(P<0.05,),与阳性对照组阿托品(0.25mg)比较;给药后20min降低肠管收缩频率为阿托品的3.8倍。给药后20min—25min降低肠管收缩幅度分别为正常对照组的50.0％和63.67％,二者比较有显著差异(P<0.05;P<0.05),降低幅度为阿托品的1.21倍。结果表明:甘草、白芍水提剂对在体肠管的运动呈明显抑制作用。The extraction of Glycyrrhiza and Paeonia (0. 21g) significantly inhibited the intestinal smooth muscle movement in rabbits and their extraction was more effective than either of them. The role in reducing frequency was stronger than in decreasing amplitude. 20 and 25 minutes after administration; the contractive frequencies were lowered by 64. 71% and 70. 59% respectively than normal group, qithwignificant difference (P<0. 05 and P<0. 01)and 3. 98 times as many as that of Atropine. 20 and 25 minutes after administration, The intestine contractive amplitudes were lowered by 50. 09% and 63. 67% respectively compared with normal group, with significant difference (P<0. 05) and 1. 21 times as many as that of Atropine. It is conclded that the inhibitive effect of Glycyrrhiza --Paeonia extraction on the intestinal smooth muscle movement is stroger than that of Atropine.

关 键 词：甘草 白芍 兔肠管 收缩频率 幅度 

分 类 号：R282.710.5[医药卫生—中药学]