大孔弱酸树脂提取西索米星的研究  

Study on the sisomicin extraction with macroporous carboxylic acid type ion exchange resins

作　　者：张星[1] 阮奇[1] 黄诗煌[1] 叶长[1] 施汉英[1] 

机构地区：[1]福州大学化学化工学院,福州350002

出　　处：《中国抗生素杂志》2003年第6期338-340,343,共4页Chinese Journal of Antibiotics

基　　金：福建省科技三项基金资助项目 (K2 0 0 1 8) ;福建省产学研基金资助项目 (闽经贸科 [2 0 0 0 ] 2 4 9号 )

摘　　要：比较几种大孔弱酸树脂和强酸 732树脂提取西索米星的交换和洗脱性能。实验表明 ,弱酸 号树脂对西索米星成品液的静态交换总量可达 18.1万 μg/ ml树脂 ,比 732树脂提高了 80 %; 号树脂 (羧基型 )吸附西索米星的最佳 p H值为 7.5左右 ,其动态交换容量比静态交换容量高 13.8%; 号树脂 (羧基型 )动态吸附、动态解吸提取西索米星的收率达 82 .6 %,比 732树脂提取收率提高 8%;用 5 %氨水动态解吸 , 号树脂 (羧基型 )比 732树脂 (磺酸基型 )易洗脱 ,且洗脱峰集中 ,不拖尾。The exchange capacity and desorption profiles of sisomicin in some macroporous carboxylic acid type ion exchange resins and the conventional sulfonic acid type ion exchange resin were compared. Primary experiments were conducted in three kinds of carboxylic acid type ion exchange resins(Resin I, II, III), and Resin I was selected for further study, and compared the specific characteristics with the sulfonic acid type resin 732. Results showed that the static exchange capacity of Resin-Ⅰto sisomicin was 18.1×10 7 μg /ml, which was 80% higher than that of sulfonic acid type resin 732. The optimum pH for adsorption of sisomicin was around 7.5; Dynamic exchange capacity of Resin-Ⅰwas further increased by 13.8% than static exchange capacity. In dynamic exchange of extraction and desorption of sisomicin, the total recovery rate was 82.6%, and it was 8% higher than using the sulfonic acid type resin 732. The elution of sisomicin was performed by use of 5% aqueous ammonia. The elution profile showed that the curve peak of Resin I was more concentrate and less tailing than the sulfonic acid type resin 732.

关 键 词：抗生素 西索米星 吸附 离子交换容量 解吸 大孔网状弱酸树脂 

分 类 号：TQ465.9[化学工程—制药化工]