培哚普利和氯沙坦逆转老年高血压左室肥厚的对比性研究  

THE EFFECT OF PERINDOPRIL AND LOSARTAN ON REGRESSION OF LEFT VENTR-ICULAR HYPERTROPHY IN ELDERLU PATIENTS WITH ESSENTIAL HYPERTENSION

作　　者：严红[1] 段小嬿[1] 闭媛媛[1] 

机构地区：[1]广西壮族自治区江滨医院,南宁530021

出　　处：《广西医科大学学报》2003年第2期203-205,共3页Journal of Guangxi Medical University

摘　　要：目的 :对比研究培哚普利和氯沙坦治疗老年高血压的疗效及对左室肥厚的逆转作用及耐受性。方法 :将 90例老年高血压伴左室肥厚的患者按数字随机法分为培哚普利组和氯沙坦组 ,于服药前及服药后 6、1 2、2 4个月分别测定血压、左室舒张末内径 (L VDd)、舒张期室间隔厚度 (IVST)、左室后壁厚度 (L VPWT)、左室射血分数 (L VEF)、心排量 (CO)、A峰 /E峰比值。结果 :两组经治疗后均有血压的下降及左室质量指数 (L VMI)的改善作用 ,但氯沙坦组不良反应少。结论Objective:To compare the effects of perindopril and losartun on reducing blood pressure and regressing left ventricular hypertrophy in elderly patients with essential hypertension (EH).Methods:90 elderly patients with EH and left ventricular hypertrophy were divided into perindopril group and losartun group. Before and after 6,12,24 months, left ventricular diastolic dismeter (LVDd), interventricular septal thickness(IVST), left ventricular posterior wall thickness(LVPWT), left ventricular mass index were measured by echo.Result:Obvious decreases in blood pressure and LVMI were observed in both groups. Conclusion:Both agents has regressive effect on LVH.

关 键 词：高血压 左室肥厚 培哚普利 氯沙坦 逆转作用 耐受性 对比性研究 

分 类 号：R544.1[医药卫生—心血管疾病] R541.3[医药卫生—内科学]