热应激蛋白60与儿童特发性血小板减少性紫癜  

Relationship between Heat Stress Protein 60 and Idiopathic Thrombocytopenic Purpura in Children

作　　者：袁明纯[1] 丁甫月[1] 陈胜[2] 肖成峰[2] 李建新[1] 邬堂春[2] 

机构地区：[1]武汉市儿童医院血液科,武汉430015 [2]华中科技大学同济医学院职业医学研究所,武汉430030

出　　处：《华中科技大学学报（医学版）》2003年第3期294-296,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省科委攻关计划资助项目 (No .2 0 0 0 2P12 0 3)

摘　　要：目的　研究特发性血小板减少性紫癜 (ITP)患儿热应激蛋白 6 0 (HSP 6 0 )水平 ,探讨HSP 6 0在ITP发生、发展中的可能作用。方法　用Westernblot法检测了 2 9例ITP患儿和 30名正常儿童外周血淋巴细胞HSP 6 0水平。结果　对照组 30名儿童均检测出HSP 6 0 ,而 2 9名ITP患儿中仅有 1人检测到HSP 6 0 ,两者具有显著性差异 (P <0 0 1)。结论　HSP 6 0与ITP的发生可能相关 。Objective To study the implication of HSP 60 level in the development of children with idiopathic thrombocytopenic purpura (ITP). Methods HSP 60 levels in lymphocytes of 29 children with ITP and 30 healthy controls were detected by using Western blot. Results HSP 60 was detectable in all 30 controls, but only one in 29 children with ITP (P<0.01). Conclusion HSP 60 may have a close relationship with ITP development and HSP 60 may play an important role in regulating autoimmunity and autoimmune diseases.

关 键 词：儿童 特发性血小板减少性紫癜 热应激蛋白60 自身免疫疾病 

分 类 号：R725.546[医药卫生—儿科]