单纯性肥胖患者脂蛋白脂酶基因多态性  

Lipoprotein lipase gene polymorphism in simple obese patients

作　　者：李蓉[1] 李启富[1] 郭立新[2] 汪恕萍[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016 [2]卫生部北京医院内分泌科

出　　处：《中华内分泌代谢杂志》2003年第3期225-227,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的 探讨脂蛋白脂酶(LPL)基因HindⅢ多态性与单纯性肥胖患者体脂分布、脂质代谢的关系。方法 采用PCR-RFLP对98例单纯性肥胖患者和51名正常对照组LPL基因第8内含子HindⅢ酶切位点进行多态性分析,并测定体脂分布指标与血脂水平。结果LPL HindⅢ位点在两组中均以H+等位基因为主。两组等位基因频率及基因型差异均无显著性,但肥胖组H+H+基因型者血浆甘油三酯水平明显增高、高密度脂蛋白胆固醇明显降低(P均<0.05),腰围、腹腔内脏脂肪面积也显著高于非H+H+基因型者(P<0.05)。结论LPL HindⅢ基因多态性对肥胖患者的血脂水平及脂肪分布有影响。具有HindⅢ酶切位点的H+等位基因可能是单纯性肥胖患者出现腹型肥胖和脂代谢紊乱的遗传易感因素之一。Objective To investigate the impact of lipoprotein lipase (LPL) gene Hind Ⅲ polymorphisms on plasma lipid and body adipose tissue distribution in simple obese patients. Methods The Hind Ⅲ site of LPL gene intron 8 was detennined by PCR-RFLP in 98 simple obese patients and 51 normal controls. Anthropometry and blood lipid levels were also measured. The parameters for regional adipose tissue distribution were measured by computerized tomography (CT). Results In both groups, H + was the major allele. There was no statistically significant difference in frequencies of genotypes or alleles between the two groups. In obese subjects, Hind Ⅲ H + H + genotype was associated with higher level of triglycerides and lower level of high density lipoprotein-cholesterol ( HDL-C) , as compared with the heterozygote (H + H - ) or homozygote ( H - H - ) genotypes (both P <0.05). Compared with subjects with H - H - and H + H - genotypes, the subjects with H + H + genotypes showed significantly larger waist circumference and abdominal visceral adipose area (both P <0. 05). Conclusion LPL Hind Ⅲ polymorphism may modify the levels of plasma triglycerides, HDL-C and adipose tissue distribution in obese subjects. H + allele may contribute to the abdominal obesity and dyslipidemia in obese patients.

关 键 词：单纯性肥胖 脂蛋白脂酶 基因多态性 体脂分布 脂质代谢 

分 类 号：R589.2[医药卫生—内分泌]