11β-羟类固醇脱氢酶与2型糖尿病  

11β Hydroxysterold dehydrogenases and type 2diabetes mellitus

作　　者：陈娜[1] 姚兵[1] 

机构地区：[1]徐州医学院药理教研室,221002

出　　处：《中华内分泌代谢杂志》2003年第3期245-247,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：11β-羟类固醇脱氢酶(11β-HSDs)催化氢化可的松(皮质酮)和可的松(脱氢皮质酮)的相互转化,对调节局部糖皮质激素的活性起着重要作用,而糖皮质激素可诱导胰岛素抵抗。肝、脂肪等组织内11β-HsD活性的改变与肥胖、2型糖尿病等疾病密切相关。11β Hydroxysterold dehydrogenases (11β-HSDs )catalyse the interconversion of active glucocorticoids(cortisol,corticosterone )and their inert 11β-keto derivatives(cortisone,11-dehydrocorticosterone)They play an important role in regulating the local glucocorticoids activities.Glucoeorticoids can induce insulin resistance.The alteration of 11β-HSD activities in tissues such as liver ,adipose tissue, is closely relevant to some common disorders,including obesity and type 2diabetes mellitus.

关 键 词：11Β-羟类固醇脱氢酶 2型糖尿病 糖皮质激素 2型糖尿病 肥胖 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]