肾小球疾病HLA易感基因研究报告  

Investigation report of renal corpuscle disease' HLA gene

作　　者：鲍长途[1] 孙利炜[1] 焦立新[1] 于露丹[1] 朴春姬[1] 郑广力[1] 王承训[1] 包进[1] 刘宇奇[1] 

机构地区：[1]长春市儿童医院,吉林长春130061

出　　处：《中国实验诊断学》2003年第3期260-263,共4页Chinese Journal of Laboratory Diagnosis

基　　金：长春市科委资助 ( 2 0 0 5 9)

摘　　要：目的　探讨肾小球疾病发生及发展与HLA等位基因的关系 ,寻找肾小球疾病HLA易感基因。方法　采用序列特异性引物 聚合酶链反应方法对肾小球疾病患儿的HLA等位基因进行分析 ,并分析了肾小球疾病患儿存在HLADRB1 15的不同临床表现。结果　肾小球疾病患儿HLADRB1 15基因频率为 16 .2 5 % ,明显高于正常对照组 ;HLADRB1 15基因在肾病综合征和急性肾小球肾炎患儿中的分布无明显差异 ;HLADRB1 15型急性肾小球肾炎和肾病综合征患儿临床症状表现重。结论　肾小球疾病的发生、发展与HLA基因型有关 ;探讨肾小球疾病的HLA基因型对于判断病情有重要意义。objective To study the relation of renal corpuscle disease' occurence and development between HLA gene and find renal corpuscle disease HLA gene which episode easily. Methods Using ssp PCR method to study children renal corpuscle disease patient's HLA gene and assay the different clinical situations of children renal corpuscle disease patients who have HLADRB 1 15 gene. Result The gene frequency of renal corpuscle disease patients is 16.25%,evidently it is higher than normal control group ; the HLADRB 1 15 gene frequency has no evident difference between nephrotic syndrome and acute nephritis , nephrotic syndrome and acute nephritis children patients who is HLADRB 1 15 have more clinical situations and more serious state of illness. Conclution The occurrence and the development of renal corpuscle disease have relations with HLADRB 1 15 ,it is important to study HLA gene of renal corpuscle disease patients for judging state of an illness .

关 键 词：肾小球疾病 HLA易感基因 研究报告 序列特异性引物-聚合酶链反应 

分 类 号：R692.3[医药卫生—泌尿科学]