麦粒灸对实验性RA大鼠足跖肿胀度及滑膜组织Caspase-3表达的影响  

Changes of Joint Swelling and Expression of Caspase-3 of Experimental Rheumatoid Arthristis Rat after Moxibustion

作　　者：黄迪君[1] 韩哲林[1] 罗荣[1] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075

出　　处：《成都中医药大学学报》2003年第2期29-30,64,共2页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家自然科学基金课题 (编号 :39870 95 6 )

摘　　要：目的　观察艾灸对实验性RA大鼠足跖肿胀度和滑膜组织Caspase - 3表达的影响。 方法　4 0只大鼠随机分为 4组 ,除空白组外 ,均用弗氏完全佐剂造模 ,麦粒灸RA大鼠“肾俞”、“足三里” ,检测滑膜组织Caspase - 3表达。 结果　造模后实验动物Caspase - 3表达增强 (P <0 . 0 1) ,经艾灸治疗后 ,足跖肿胀度降低 (P <0 . 0 1) ,Caspase - 3较模型组增加 (P <0 . 0 1)。 结论　艾灸治疗可增强局部组织中Caspase - 3的表达 ,提示艾灸可能通过促进局部组织炎性细胞的凋亡 ,抑制局部组织的增生 ,以减轻局部组织的炎症。Objective:To observe the changes of joint swelling and the expression of Caspase-3 of experimental rheumatoid arthristis (RA) rat after moxibustion. Methods:Dividing 40 rats into 4 groups. Treating the 'shenshu', 'zusanli' of RA rats with moxibustion. Observing swelling degrees of rat foot-soles and the expression of Caspase-3 in synovial tissues of lesion joints.Result:The expression of Caspase-3 in model rats arise (P<0.01), after treatment with moxibustion, swelling degree of rat foot-soles reduces obviously and the expression of Caspase-3 advances obviously (P<0.01). Conclusion:Moxibustion can advance the expression of Caspase-3 in synovial tissues of lesion joints to improve the apoptosis and inflammation and relieve local inflammatory reaction and edema

关 键 词：麦粒灸 实验性RA大鼠 足跖肿胀度 滑膜组织 Caspase—3 表达 

分 类 号：R246.1[医药卫生—针灸推拿学] R593.21[医药卫生—中医临床基础]