壳聚糖絮凝法用于脑清口服液澄清工艺的探讨  

Study on clarifying for Naoqing Oral Liquid with chitin instead of ethanol

作　　者：李冬梅[1] 路绪文[1] 苏芳[2] 

机构地区：[1]解放军第251医院,河北张家口075000 [2]解放军白求恩军医学院,河北石家庄050081

出　　处：《中成药》2003年第6期448-450,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :探讨壳聚糖絮凝法代替乙醇沉淀法用于脑清口服液 (葛根 ,黄芪等 )制备的可行性。方法 :考察两种澄清法的沉淀效果、过滤难易、对主要有效成分含量影响并对稳定性进行了比较。结果 :壳聚糖絮凝法与醇沉法同样能使药液澄清 ,前者能更有效地保留药液中的有效成分 ,又能保证制剂的稳定性 ,缩短生产周期 ,降低成本。结论Objective: To study clarifying for Naoqing Oral Liquid (Radix Puerariae, Radix Astragali, etc.) with chitin instead of ethanol. Methods: By studying precipitation effect of two clarification methods, in the meantime, studying the influence of different concentration of chitin on the clarification effect of Naoqing Oral Liquid. Results: Chitin had the more effective components than ethanol, and assured the stability of the preparation and shortened production period of the preparation. Conclusion: Chitin can clarify Naoqing Oral Liquid instead of ethanol.

关 键 词：脑清口服液 乙醇沉淀法 壳聚糖 絮凝法 葛根素 黄芪甲苷 HPLC 澄清工艺 制备 

分 类 号：R944.1[医药卫生—药剂学] R283.6[医药卫生—药学]