芦白胶囊的活血化瘀作用  

Promoting blood circulation by removing blood stasis of Lubai Capsule

作　　者：赵万红[1] 曹永孝[2] 刘静[2] 王德俭[2] 石巧娟[2] 林长征[2] 郑建普[2] 

机构地区：[1]郧阳医学院,湖北十堰442000 [2]西安交通大学药学院,陕西西安710061

出　　处：《中成药》2003年第6期480-483,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :观察芦白胶囊 (芦根 ,白芍 ,防风 ,荆芥穗等 )的活血化瘀作用。方法 :用冰水中游泳和sc注射肾上腺素制造大鼠急性血瘀模型 ,观察芦白胶囊对血液流变性的影响 ;用肾上腺素制造大鼠肠系膜急性微循环障碍模型 ,观察其对微循环障碍的改善作用 ;以体外法 ,用PT及KPTT试剂盒测定血液凝固时间 ,观察该药对凝血酶原时间 (PT)及活化部分凝血活酶时间 (KPTT)的影响。结果 :芦白胶囊能明显降低大鼠的全血粘度、血浆粘度、血纤维蛋白原含量、血沉及血小板粘附率 ,减轻血瘀大鼠血液的粘、凝状态 ,防止血栓形成 ;可抑制肾上腺素引起的大鼠肠系膜微循环细动脉管径缩小、流速减慢、毛细血管开放量减少、流态改变 ,并改善这些现象 ;可显著延长家兔PT及KPTT。结论 :芦白胶囊有改善血液流变性及微循环障碍的作用 ,有抑制内源性及外源性凝血系统的作用 。Objective: To observe the promoting blood circulation by removing blood stasis of Lubai Capsule(LBC)(Rhizoma Phragmitis, Radix Paeoniae Alba, Radix Saposhnikoviae, Flos Schizonepetae, etc.). Methods: Acute blood stasis rat models were established with swimming in iced water and sc adrenalin in order to observe the effect of LBC on blood rheology. Mesenteric microcirculatory disturbance rat models were also established with adrenalin in order to observe the effect of LBC. Clotting time was measured in vitro with prothrombin time(PT) and kaolin partial thromboplastin time(KPTT) kit in order to observe its effects. Results: LBC could decrease the whole blood and plasma viscosity, fibrinogen, erythrocyte sedimentation and aggregation ratio of blood platelets of rats, ease the sticky condition of blood stasis rat models and prevent from forming thrombus. It could also inhibit the constraction and slowing of blood flow of thin artery, the reducing of open capillaries and change of fluid condition caused by adrenalin and improve these phenomena. PT and KPTT could be increased obviously. Conclusion: LBC can significantly promote blood circulation by removing blood stasis, because of improving blood rheology and mesenteric microcirculatory disturbance and inhibit endogenous and exogenous coagulation system.

关 键 词：芦白胶囊 血液流变性 微循环障碍 活血化瘀作用 

分 类 号：R285.6[医药卫生—中药学]