One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Using TsOH as a Catalyst under Microwave Irradiation  

作　　者：屠树江 房芳 缪春宝 蒋虹 史达清 

机构地区：[1]Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu 221009, China

出　　处：《Chinese Journal of Chemistry》2003年第6期706-709,共4页中国化学（英文版）

基　　金：ProjectsupportedbytheNaturalScienceFoundationofJiangsuProvince (No .BK2 0 0 114 2 )andtheNaturalScienceFoundationofJiang suEducationDepartment (No .0 1KJB15 0 0 0 8)andJiangsuProvinceKeyLaboratoryofChemical&EngineeringandTechnologyFounda tion (No .KJ

摘　　要：A series of Biginelli compounds was synthesized using TsOH as a catalyst under microwave irradiation. This simple method provided the title compounds in 86%-98% yields by the reaction of aromatic aldehydes with 1,3 carbonyl compound and urea. The structure of 4o was determined by single crystal X ray diffraction analysis.A series of Biginelli compounds was synthesized using TsOH as a catalyst under microwave irradiation. This simple method provided the title compounds in 86%-98% yields by the reaction of aromatic aldehydes with 1,3 carbonyl compound and urea. The structure of 4o was determined by single crystal X ray diffraction analysis.

关 键 词：DIHYDROPYRIMIDINONES Biginelli reaction micro  wave TsOH 

分 类 号：O621.3[理学—有机化学]