卤代水杨醛N^-4取代缩氨基硫脲衍生物的合成和生物活性研究  

Synthesis and biological activity studies of halogenated salicylaldehyde N^4-thiosemicarbazone derivatives

作　　者：柳翠英[1] 葛蔚颖[1] 钱俊 李忠[1] 于爱华[1] 

机构地区：[1]山东大学药学院,济南250012 [2]山东正大福瑞达制药有限公司,济南250014

出　　处：《化学试剂》2003年第3期160-162,共3页Chemical Reagents

摘　　要：以R—NH2 、CS2 、水合肼、水杨醛等为原料设计合成了 6种未见文献报道的卤代水杨醛缩N4 羟基乙基 /邻甲苯基氨基硫脲 ,其组成与结构由元素分析、红外光谱所证实。体外抑菌试验表明 ,合成的化合物均有较强的抑菌活性 ,说明卤代水杨醛N4 取代缩氨基硫脲是一类新型的有重要研究价值的抗菌剂。Six types of new halogenated salicylaldehyde N 4 hydroxyethyl / o tolyl thiosemicarbazine were synthesized with R-NH 2,CS 2,hydrazine hydrate?salicylaldehyde as raw materials,which have not been reported before.The chemical structures were identified by elemental analysis,IR spectra and their antibacterial activities have been tested in vitro against six kinds of bacteria.Compounds 3a～3f showed significant antibacterial activities.As new kinds of promising antibacterial agents,halogenated salicylaldehyde N 4 thiosemicarbazone derivatives are worthy to be studied.

关 键 词：卤代水杨醛 N^4-取代缩氨基硫脲衍生物 合成 生物活性 抗菌剂 

分 类 号：TQ465[化学工程—制药化工] O625.7[理学—有机化学]