高效液相色谱法分离测定洛伐他汀及其开环酸  

Determination of Lovastatin and Lovastatin Acid by High Performance Liquid Chromatography

作　　者：杜方鸣[1] 于燕梅[1] 李洲[1] 林仙武 

机构地区：[1]清华大学化学工程系,北京100084 [2]浙江瑞邦大药厂,浙江温州325027

出　　处：《分析测试技术与仪器》2003年第2期95-97,共3页Analysis and Testing Technology and Instruments

摘　　要：改进了洛伐他汀的分析方法,以甲醇∶水=80∶20为流动相,采用紫外检测器检测,使用C4色谱柱定性、定量分析了洛伐他汀及洛伐他汀羟基酸,并得出了相关方程.实验证明,采用新的色谱条件可在有效地分析洛伐他汀及其开环酸的基础上,节约分析成本.An improved reverse phase HPLC method has been established to determine lovastatin and lovastatin acid. The C\-4 column and the UV detector were applied, and methanolwater(80∶20) was used as the mobile phase. The experimental results show that the improved chromatographic conditions can be used to analyze the lovastatin and lovastatin acid effectively and economically.

关 键 词：高效液相色谱法 分离 测定 洛伐他汀 开环酸 降血脂药物 

分 类 号：R972.6[医药卫生—药品] R927.2[医药卫生—药学]