微量元素镉 硒对NIH小鼠超氧化物歧化酶的影响  

The influence of Trace element Cadmium and Selenium Upon Superoxide dismutase in NIH mouse

作　　者：魏经建[1] 刘彩玉[1] 

机构地区：[1]河南省肿瘤研究所,郑州450003

出　　处：《微量元素与健康研究》2003年第3期3-5,共3页Studies of Trace Elements and Health

摘　　要：目的 :了解镉、硒对NIH小鼠超氧化物歧化酶 (SOD)活性变化的作用。方法 :采用Oyanagui和贺锐的方法测定Cu—ZnSOD和Mn—SOD活性。结果和结论 :镉能使NIH小鼠内脏组织细胞的Cu—ZnSOD活性降低 ,Mn—SOD活性相应增高 ,硒能拮抗这种作用 。objective: A explore the variation for Trace element cadmium and selenium upon Superoxide dismutase activity (SOD)in NIH mouse. Methods: We determined the activity of Cu-Zn SOD and Mn-SOD With Oyanagui and Herui's methods. Results and Conclusion: The result suggested that the Cadmium have been made the Cu-Zn SOD activity level of tissue cell in internal organs decrease?and had a activity of Mn-SOD Were more higher. Selenium have a antagonize. We have elucidated the mechanism of carcinogenesis of cadmium at a enzymologic angle.

关 键 词：微量元素 镉 硒 NIH 小鼠 超氧化物歧化酶 影响 

分 类 号：R995[医药卫生—毒理学] R977.9[医药卫生—药学]