阿替洛尔和地尔硫对高血压患者的血压和生活质量的影响  

Effects of atenolol and diltiazem-SR on quality of life in the hypertensive patients

作　　者：姚雪艳[1] 范维琥[2] 陈君柱[1] 朱建华[1] 陈宝仙[1] 刘晓健[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003 [2]复旦大学医学院附属华山医院,上海200040

出　　处：《浙江大学学报（医学版）》2003年第3期231-234,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：国际临床流行病网 (INCL EN;Inc)

摘　　要：目的 :比较阿替洛尔片和地尔硫缓释胶囊治疗轻中度高血压患者的血压、心率和生活质量的影响。方法 :73例轻中度原发性高血压 (舒张压 90～ 10 9mm Hg)患者被随机分 2组 ,分别服用阿替洛尔片 2 5 mg/ d(A组 ,n= 37)和地尔硫缓释胶囊 90 mg/ d(B组 ,n=36 )。比较治疗前及治疗 8周后对心率、诊所血压 (OBP)、动态血压(ABP)和生活质量的影响。结果 :服药 8周后 A组和 B组心率分别下降 (11.2± 12 .4 )次 / min和 (8.8± 6 .3)次 /min,OBP分别下降 (2 1.1± 10 .0 / 19.1± 7.6 ) mm Hg和 (2 8.1± 10 .4 / 2 0 .7± 6 .7) mm Hg,A组和 B组降压有效率分别为 88.2 %和 93.8%。A、B两组 ABP日间平均收缩压和舒张压分别下降 (10 .3± 14 .2 / 6 .2± 8.5 ) mm Hg和 (8.1± 12 .4 / 6 .9± 7.9) mm Hg,夜间平均收缩压和舒张压分别下降 (9.4± 14 .3/ 5 .9± 10 .5 ) mm Hg和 (6 .8± 11.0 / 5 .4±8.1) mm Hg,组内治疗前后比较差异有显著性 (P<0 .0 5～ 0 .0 1)。服药 8周后两组在躯体健康、心理健康和社会功能方面均有不同程度的改善 ,组内比较示 B组躯体健康改善有统计学意义 (P<0 .0 5 )。A组和 B组不良反应发生率分别为 2 1.6 %和 11.1%。结论 :阿替洛尔和地尔硫均有较好的降压作用 ;阿替洛尔减慢心率?Objective: To compare the efficacy of atenolol and diltiazem-SR and the effects on the quality of life in hypertensive patients.Methods:Seventy-three patients with mild to moderate hypertension (DBP 90～109 mmHg) were allocated randomly to be administered with atenolol 25 mg/d (group A,n=37) and diltiazem-SR 90 mg/d (group B,n=36) for eight weeks.The changes of heart rate,office blood pressure(OBP),ambulatory blood pressure(ABP) and the quality of life were compared before and after treatment.Results:Heart rate,OBP and ABP decreased after treatment in both groups.The effective rate of blood pressure was 88.2% in group A and 93.8% in group B.Twenty-four-hour mean daytime and nighttime BP,daytime and nighttime BP loads declined in both groups (P<0.05～0.01).The quality of life was significantly increased in group B (P<0.05).Side effects were 21.6% in group A and 11.1% in group B,respectively (P>0.05).Conclusion:Atenolol and diltiazem-SR are more effective and tolerant in the treatment of the hypertension.Diltiazem improves the quality of life better than atenolol.

关 键 词：高血压 阿替洛尔 地尔硫ZHUO 血压 心率 生活质量 药物疗法 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]