乙肝疫苗免疫后无(弱)应答影响因素的分析  

Analysis of the impact factors in non-responsiveness ( slow- responsiveness) after vaccination of hepatitis B vaccine

作　　者：陈敏[1] 陈清[1] 陈思东[2] 王德全[2] 蔡旭玲[2] 何炳欣[3] 黄祖星[3] 陈抒豪[3] 

机构地区：[1]第一军医大学流行病学教研室,广东广州510515 [2]广东药学院流行病学教研室,广东广州510224 [3]佛山市疾病预防控制中心,广东佛山528000

出　　处：《广东药学院学报》2003年第2期173-175,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省自然科学基金(020537)

摘　　要：目的:分析影响乙肝疫苗免疫后无(弱)应答的因素。方法:选择经乙肝疫苗全程注射的中小学生975人进行研究,采用酶联免疫测定和固相放射免疫方法检测抗-HBs,并调查他们的各种暴露情况,根据检测后抗-HBs阴性和阳性分组,应用病例对照分析方法进行资料处理。结果:该人群乙肝疫苗无应答率24％。多因素Logistic回归分析结果表明,对乙肝疫苗应答的主要影响因素有:接种部位(OR=0.54,95％CI:0.37-0.79),有无不适感(OR=1.13,95％CI:1.003-1.27)。结论:无(弱)应答与机体的年龄、接种部位、接种后有无不适感、饮酒存在一定联系。To analyze the impact factors of non-responsiveness ( slow-responsiveness) after vaccination of hepatitis B (HB) vaccine Methods; 975 middle and elementary school students, who were vaccinated with HB vaccine for the whole course, were enrolled into the study. Their HBsAb levels were detected by ELISA and SPRIA. Their exposure status were investigated, and they were grouped according to their HBsAb results. The data were analyzed by case-control method. Results; The non-responsiveness ( slow-responsiveness) rate in this group of students was 24% . Logistic analysis indicated that the main impact factors of responsiveness to hepatitis B vaccine were the vaccination site( OR =0. 54 ,95% CI:0. 37 -0.79)and the physical status after vaccination ( OR = 1. 13, 95% CI; 1.003 -1.27). Conclusion; non-responsiveness (slow-responsiveness) is associated with the age, vaccination site, the physical status after vaccination and alcohol drinking.

关 键 词：乙肝疫苗 免疫后 无(弱)应答 影响因素 分析 

分 类 号：R186[医药卫生—流行病学]