性激素对大鼠缺氧、再给氧心肌过氧化脂质含量的影响  

Effects of sex hormones on contents of myocardial lipid peroxidation caused by hypoxemia and reoxyge nation

作　　者：陈晓光[1] 郭忠兴[1] 赵玉珍[1] 李怀荆[1] 周敏[2] 宋春燕[2] 常福久[2] 

机构地区：[1]佳木斯医学院药理教研室 [2]黑龙江中医学院药理教研室

出　　处：《佳木斯医学院学报》1989年第4期316-319,396,共4页

摘　　要：进行离体大鼠心脏灌流,缺氧再给氧后制备心肌匀浆,采用TBA反应比色法测定MDA含量。结果表明;丙酸睾丸素(8μg/kg、64μg/kg)、己烯雌酚(3.2μg/kg、12.8μg/kg)对缺氧、再给氧心肌MDA含量均有明显的降低作用,并分别与抗氧化剂V_E100μM、200μM作用相似,与老化有关。The heart perfusion was carried out in rats in vitro.Following hypoxemia and reoxygenation, herat sarcolemmal was made. Methyldialdehyde (MDA) contents were measured using TBA photocolorimetric method. The results in- dicated that testosterone propionate (8μg/kg, 64μg/kg) and diaethylstilbes- trolum (3.2μg/kg, 12.8μg/kg) could decrease the myocardial MDA contents induced by hypoxemia and reoxygenation and the free radical-induced lipid peroxidation. These results suggest that testosterone propionate and diethylstil- bestrolum may inhibit free radical formation and protect heart muscle from myocardial damage by reperfusion.

关 键 词：性激素 过氧化脂质 缺氧再给氧 

分 类 号：R977.12[医药卫生—药品]