系统性红斑狼疮患者抗磷脂抗体与视网膜血管病关系的研究  

Relationship between Re tinal Vasculopathy and Antiphospholipid Antibodies in Patients with Systemic Lup us Erythematosus.

作　　者：刘岩[1] 熊毅彤[1] 翁欢[1] 徐康[1] 李秋华[1] 

机构地区：[1]复旦大学附属华山医院眼科,200040

出　　处：《诊断学理论与实践》2003年第2期133-134,共2页Journal of Diagnostics Concepts & Practice

摘　　要：目的:研究系统性红斑狼疮(systemiclupuserythematosus,SLE)抗磷脂抗体等血清免疫学标志物与患者视网膜血管病的关系。方法:从2002年6月至2003年1月,对164例SLE患者作最佳矫正视力检查、眼压测量、裂隙灯检查和眼底检查,血清免疫学检查指标包括抗心磷脂抗体(anticardiolipinantibody,ACL)、狼疮抗凝物(lupusanticoagulant,LA)、抗核抗体(antinuclearantibody,ANA)和抗ds鄄DNA抗体等。结果:164例SLE患者中26例(16%)检查到有视网膜血管病,其中19例(73%)检测到抗磷脂抗体(17例ACL和2例LA)。结论:SLE患者易发生视网膜血管病变,抗磷脂抗体的存在可能与其有较高的相关性。Objective:To study the rel at ionship between retinal vasculopathy and antiphospholipid antibodies(APL)in pati ents with systemic lupus erythematosus(SLE).Methods:From Jun2002through Jan2003, 164patients with SLE were examined by corrected visual acuity,intraocular pressu re tonometry,slit-lamp and funduscope exam and some serological markers,such as anticardiolipin antibody(ACL),lupus anticoagulant(LA),antinuclear antibody(ANA )and anti-ds-DNA antibody.Results:Among164patients with SLE,retinal vasculopa thy was found in26(16%)cases and APL was found in19cases(73%)of them(17cases of ACL and2cases of LA).Conclusions:Retinal Vasculopathy is probably highly related to APL in patients with SLE.

关 键 词：系统性红斑狼疮 抗磷脂抗体 视网膜血管病 抗心磷脂抗体 狼疮抗凝物 抗核抗体 

分 类 号：R593.241[医药卫生—内科学]