心痛康胶囊质量标准研究  

Studies on Quality Standard of Xintongkang Capsules

作　　者：张蕾[1] 莫奇萍[1] 刘舞霞[1] 董小平[1] 

机构地区：[1]江苏省药品检验所,南京210008

出　　处：《江苏药学与临床研究》2003年第3期20-23,共4页Jiangsu Pharmacertical and Clinical Research

摘　　要：目的　建立心痛康胶囊质量标准。方法　对红参进行显微鉴别 ,白芍和淫羊藿进行薄层鉴别 ,并用HPLC法测定制剂中芍药苷和淫羊藿苷的含量。结果　显微鉴别特征明显 ,薄层图谱斑点清晰 ,阴性对照无干扰 ,芍药苷在 2 5 34～ 12 6 70 μg间、淫羊藿苷在 1 96～ 17 6 6 μg间呈现良好的线性关系 ;芍药苷回收率为 99 5 1% ,RSD为 1 2 9% ,淫羊藿苷回收率为 99 11% ,RSD为 1 6 2 %。结论　结果准确 ,重复性好 ,可用于该制剂的质量控制。Objective To estabilish the quality standard for Xintongkang capsules.Methods Radix Ginseng was identified by microscopie, Radix Paeoniae Alba and Herba Epimedii were identified by TLC.Paeoniflorin and icariin were determined by HPLC.Results The microscopis characteristics were obvious.The TLC spots developed were fairly clear,and the blank test showed no interference.A good linearity for paeoniforin was ranged from 25.34 to 126.70 μg and that for icariin was ranged from 1.96 to 17.66 μg.The average recovery of paeoniflorin was 99.51%(RSD=1.29%)and that of icariin was 99.11%(RSD=1.62%).Conclusion The result is accurate and the reproducibility is good. This method can be used for quality control of capsules.

关 键 词：心痛康胶囊 质量标准 研究 芍药苷 淫羊藿苷 含量测定 

分 类 号：R972[医药卫生—药品] R927.2[医药卫生—药学]