萘酚喹对云南间日疟和抗药性恶性疟的预防效果  

PREVENTIVE EFFECT ON NAPHTHOQUINE AGAINST VIVAX MALARIA AND DRUG RESISTANT FALCIPARUM MALARIA IN YUNNAN, CHINA

作　　者：杨恒林[1] 李兴亮[1] 杨品芳[1] 李春富[1] 吴超[1] 张志勇[1] 高白荷[1] 

机构地区：[1]云南省寄生虫病防治所,云南思茅665000

出　　处：《中国寄生虫病防治杂志》2003年第3期137-139,共3页Chinese Journal of Parasitic Disease Control

摘　　要：目的　评价萘酚喹对云南间日疟和抗药性恶性疟的预防效果 ,指导高危人群预防服药。　方法　在中缅、中老边境地区的云南省勐腊县和景洪市选择发病率 >5 %的村庄 ,随机分为萘酚喹 (A、B)组和空白对照 (C)组。A组成人每月顿服萘酚喹 4片 (4 0 0 mg) ,连服 2月。B组成人顿服萘酚喹 4片 ,观察 1个月。　结果　A组带虫率从服药前的 7.4 0 %(33/ 4 46 )下降到用药后的 0 .6 8% (3/ 4 43) ,下降 90 .81% ;B组带虫率从服药前的 5 .5 0 % (11/ 2 0 0 )下降到用药后的2 .6 9% (5 / 186 ) ,下降 5 1.0 9% ;C组带虫率较观察前上升 6 7.99%。　结论　萘酚喹对云南间日疟和抗药性恶性疟有良好的预防效果 ;在发病率较高地区 A组预防效果优于 B组。Objective To evaluate the preventive effect of naphthoquine against vivax malaria and chloroquine-resistance falciparum malaria. Methods The study was carried out in villages with 5% over of carrying malaria plasmodium rate in Jinghong and Mengla Counties, where are epidemic vivax and chloroquine-resistance falciparum malaria and located China-Mynamar and China-Laos border areas. 1 547 persons enrolled into the study and were divided three groups: Group A, adults were given 4 tablets (400 mg) naphthoquine in single time per month, two consecutive months; Group B, adults were given 4 tablets (400 mg) naphthoquine in single time, only one month; Group C taken placebo as control. Results Carrying malaria plasmodium rate dropped 90.81% (from 7.40% before treatment to 0.68% after treatment) in group A; Descended 51.09% (from 5.50% before treatment to 2.69% after treatment) in group B; In group C, carrying malaria plasmodium rate rose up 67.99% (from 9.81% before treatment to 16.48% after treatment). Conclusion Naphthoquine has a good preventive effect on vivax malaria and chloroquine-resistance falciparum malaria and preventive effect of group A is better than that of group B.

关 键 词：萘酚喹 云南 间日疟 抗药性恶性疟 预防 疟疾 安慰剂 质量控制 

分 类 号：R531.3[医药卫生—内科学]