阿苯达唑治疗前后泡状棘球蚴病患者淋巴细胞亚群变化及临床意义  

IMMUNOLOGICAL MARKER INDICATING THE CURATIVE EFFECTS OF TREATMENT IN AE PATIENTS USING ALBENDAZOLE

作　　者：李富荣[1] 石佑恩[2] 史大中[3] DA Vuitton PS Craig 

机构地区：[1]深圳市人民医院〈暨南大学医学院第二附属医院〉临床医学研究中心,广东深圳518020 [2]华中科技大学同济医学院寄生虫学教研室,湖北武汉430030 [3]兰州医学院寄生虫学教研室,甘肃兰州730000 [4]Centre Hospitalier Universitaire [5]Department of Biological Sciences

出　　处：《中国寄生虫病防治杂志》2003年第3期167-169,共3页Chinese Journal of Parasitic Disease Control

基　　金：欧共体基金资助项目 (STD- 2 )~~

摘　　要：目的　探讨泡球蚴病患者经阿苯达唑治疗后 ,机体免疫应答的状态和对病程转归的影响。　方法　 7例未治疗泡球蚴病患者 ,6例经阿苯达唑治疗 12个月泡球蚴病患者 ,6例经阿苯达唑治疗 2 4个月泡球蚴病患者和 18例非流行区健康人群 ,用 FCM分析了 CD3+ 、CD4 + 、CD8+ 、CD1 9+ 、CD38+ 、CD1 6 + 56 + 和 HL A- DR+ 细胞的数量。　结果　治疗 12个月后 ,患者 CD8+细胞数继续上升 (P<0 .0 1) ,CD4 + / CD8+比值进一步倒置 ;治疗 2 4个月后 ,CD4 +细胞数开始升高 (P<0 .0 5 ) ,CD8+ 细胞数下降 ,CD4 + / CD8+ 比值升高 (P<0 .0 5 ) ;CD1 9+ 细胞在治疗 2 4个月后显著性升高 (P<0 .0 5 ) ;CD38+ 和 HL A-DR+ 细胞在治疗 2 4个月后呈显著性下降 (P<0 .0 1)。　结论　泡球蚴病患者治疗后 ,CD8+ 细胞引起的免疫抑制状态有所减轻 ,机体的保护性免疫应答有所恢复。Objective To explore immunological marker and the outcome of disease after pharmacological treatment in human AE using albendazole. Methods AE patients were treated with albendazole, 6 cases for 12 months, 6 cases for 24 months, 7 cases were not treated and 18 controls. CD 3+, CD 4+, CD 8+, CD 19 +, CD 38 +, CD 16+56 +, HLA-DR+ lymphocytes were analyzed using FCM. Results CD 8+ lymphocyte continuous increase, mean while CD 4+/CD 8+ ratio was gradually descent in group of treating for 12 months compared with group of no treatment. After treatment of 24 months, CD 4+ lymphocyte, CD 4+/CD 8+ ratio began rising, and CD 8+ lymphocyte decreased. CD 19 + lymphocyte was higher, and CD 38 + lymphocyte and HLA-DR+ lymphocytes were lower in group of treating for 24 months as compared with group of no treatment and treating for 12 months. CD 3+ lymphocyte and CD 56 + lymphocyte were not changed in all patients during treatment. Conclusion CD 8+ cell and T suppression response appeared weakness and T helper response got strong in AE patients treated with albendazole. T helper cell activation in protective immunity was recovered.

关 键 词：阿苯达唑 治疗前 治疗后 泡状棘球蚴病 淋巴细胞亚群 机体免疫应答 

分 类 号：R978.6[医药卫生—药品] R532.32[医药卫生—药学]