电穿孔下离子型药物透皮扩散的一类数学模型及其建模方法论  

A Kind of Mathematical Model for Transdermal Permeation of Ionic Drug Using Electroporation and Their Modeling Methodology

作　　者：吴建军[1] 

机构地区：[1]浙江大学数学系,浙江杭州310006

出　　处：《生物数学学报》2003年第2期211-217,共7页Journal of Biomathematics

摘　　要：在分子型模型的基础上,导出了离子型药物经皮渗透过程的一类数学模型,并用计算机模拟了其特性。而且针对分子型和离子型模型中,待估参数相对于实验样本点而言过多,同时需处理大批在不同实验控制条件下的数据资料的情形,讨论了其建模方法论问题。In this paper, on the basis of the molecular drug model, a kind of mathematical model of electroporation which may created new aqueous pores in skin for ionic drug delivery is given by two paths with quick-slow respondences separately under the Fick's diffusion law. And for the fact that estimated model parameters are too many relative to the sample sizes, and a lot set of data must be analyzed under various controlled conditions in different experiments, their modeling methodology is discussed.

关 键 词：离子型药物 透皮扩散 数学模型 电脉冲穿孔 

分 类 号：R911[医药卫生—药学]