肝硬化患者血浆ET-1、NO与门脉血流量测定及其意义  

The Mensuration of Plasma Levels of Endothelin-1, Nitric oxide and the Blood Quantites of Portal Vein in Patients with Liver Cirrhosis

作　　者：李学锋[1] 宋政军[1] 

机构地区：[1]西安交通大学第一医院,陕西西安710061

出　　处：《现代检验医学杂志》2003年第3期46-47,共2页Journal of Modern Laboratory Medicine

摘　　要：目的 研究肝硬化患者不同肝功能状态下血浆ET-1、NO及门脉血流量(Qpv)的变化规律并探讨三者间的关系。方法 采用放射免疫分析法、分光光度法及彩色多普勒超声检查,测定30例肝硬化患者血浆ET-1、NO及门静脉宽度(Dpv)、门静脉血流速度(Vpv)并与8例健康献血员进行对比分析。结果 肝硬化组血浆ET-1、NO均显著高于正常对照组;其门静脉血流量(Qpv)显著低于正常对照组。根据肝功能Child-pugh分级,肝功能A级与对照组对照,ET-1、NO均无显著性差异,Qpv有显著性差异;B级与A级、C级与B级间上述三指标均有显著性差异。结论 肝硬化患者血浆ET-1、NO升高,Qpv减少。ET-1、NO参与了肝硬化肝功能的损害及门脉高压的形成和发展。Objective To study the relation of plasma levels of endothelin-1 ,nitric oxide and the blood quantities of portal vein in patients with liver cirrhosis,and compare with Child-Pugh A,B,C and the health. Methods To measure the plasma levels of ET-1,NO,the diameter of portal vein and velocity of portal blood in 30 patients with liver cirrhosis,with radioim-munoassay ,spectrophotomctry and colour duplex ultrasound .and the result was compared with that of 8 health. Result It showed that the plasma levels of both ET-1 and NO in patients with liver cirrhosis were markedly higher than that of the health;the blood quantities of portal vein in patients with liver cirrhosis were markedly lower than that of the health. With the liver founction Child-Pugh grades. Compared grade A with the hearlth, ET-1 and NO had no markedly difference,Qpv had markedly difference. Compared grade B with grade A,and grade C with grade B,the plasma levels of ET-1,NO and the blood quantities of portal vein all had significantly difference. Conclusion The plasma levels of ET-1 and NO in patients with liver cirrhosis were increased parallel and the Qpv decreased parallel. They take part in the process of liver cirrhosis together.

关 键 词：肝硬化 内皮素—1(ET—1) 一氧化氮(NO) 门静脉血流量 

分 类 号：R446.11[医药卫生—诊断学] R575.2[医药卫生—临床医学]