2型糖尿病患者血浆ET、血清IL-6、TNF-α变化的临床意义  

Clinical Significance of Changes of Plasma Concentration of Endothelium and Serum Levels of Interleukin-6 and Tumor Necrosis Factor in Patients with type 2 Diabetes Mellitus

作　　者：谢建平[1] 张国元[2] 李素平[1] 吴成秀[1] 孙跃军[1] 严宗逊[3] 

机构地区：[1]川北医学院附属医院核医学科,637000 [2]川北医学院附属医院检验科,637000 [3]川北医学院附属医院内分泌科,637000

出　　处：《放射免疫学杂志》2003年第3期142-144,共3页Journal of Radioimmanology

摘　　要：目的 :探讨 2型糖尿病患者血浆内皮素 (ET)、白介素 - 6 (IL - 6 )、肿瘤坏死因子 (TNF -α)在糖尿病发生、发展过程中的浓度变化及相互关系。方法 :用放射免疫分析检测 6 1例 2型糖尿病患者及 33例年龄和性别相匹配的健康志愿者血清ET、IL - 6、TNF -α的水平。结果 :① 2型糖尿病患者血中ET、IL - 6、TNF -α水平明显高于正常对照组 (p <0 0 1) ;②有合并症患者血清ET、TNF -α水平明显高于单纯糖尿病患者 (p <0 0 2 ) ;③三种细胞因子间浓度水平呈正相关 (p<0 0 1)。结论 :细胞因子ET、IL - 6、TNF -α在糖尿病的发生、发展过程中相互作用 ,观察其浓度变化对探讨糖尿病的发病机理、预防及指导用药均有重要价值。Objective To determine the changes of plasma endothelium (ET) and serum interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) concentrations in patients with type 2 diabetes mellitus. Methods Plasma ET and serum IL-6 and TNF-α levels were measured by radioimmunoassy in 61 cases of type 2 diabetes mellitus (DM) 36 without complication and 25 cases with complications and 33 controls. Results (1) The plasma levels of ET and serum levels of IL-6 and TNF-α in patients with type 2 diabetes mellitus were significantly higher than those in the controls ( p <0 01); (2) The blood levels of ET, TNF-α in patients with complications were significantly higher than those in patients without complications ( p <0 02); (3) The blood levels of ET, IL-6 and TNF-α were mutually positively correlated. Conclusion Moritoring of ET,IL-6 and TNF-α levels in diabetic patients can provide additional valuable information for assessing the course of disease and efficacy of management.

关 键 词：2型糖尿病 血浆 ET 血清 IL-6 TNF-α 内皮素 白介素-6 肿瘤坏死因子 放射免疫分析 

分 类 号：R587.1[医药卫生—内分泌]