辛伐他汀对2型糖尿病患者骨密度的影响  

Effect of Simvastatin on Changes of Bone Mineral Density in Patients with Type 2 Diabetes Mellitus

作　　者：周向宏[1] 季彦[1] 黄怀宇[1] 严建军[1] 蒋葵[1] 谢晓谦[1] 薛群[1] 王雪芹[1] 

机构地区：[1]江苏省南通市第一人民医院,226001

出　　处：《中国微循环》2003年第3期171-172,共2页Journal of Chinese Microcirculation

摘　　要：目的 观察辛伐他汀对2型糖尿病患者骨密度的影响。方法 69名2型糖尿病患者,基础对照组(33例,未服用他汀类药物)和辛伐他汀组(36例,服用辛伐他汀),分别比较两组临床和生化实验室指标,以及骨密度各参数。结果 两组在临床和生化实验室指标上无显著差异。在男性和女性患者中,辛伐他汀组骨密度各参数高于基础对照组,有显著性差异。结论 辛伐他汀可改善微循环障碍和血液流变学异常,可以增加2型糖尿病患者的骨密度。Objective To investigate the effect of simvastatin on changes of bone mineral density in patients with type 2 diabetes mellitus.Methods Sixty-nine type 2 diabetic patients were studied. The control group (n = 33) did not take HMG-CoA reductase inhibitors. The treatment group (n = 36) was administered simvastatin. The clinical and biochemical parameters and BMD (bone mineral density) of two groups were measured. Results There was no significant difference between control and treatment groups in clinical and biochemical parameters, the BMD of treatment group is higher than that of control group both in male and female subjects. Conclusions Simvastatin may increase BMD of patients with type 2 diabetes mellitus.

关 键 词：辛伐他汀 2型糖尿病 骨密度 微循环障碍 血液流变学异常 

分 类 号：R587.1[医药卫生—内分泌]