非创伤性股骨头坏死与血浆脂蛋白的相关性研究  

A study on the relationship between plasma lipoprotein and non-traumatic necrosis of the femoral head

作　　者：陈卫衡[1] 林娜[2] 郭效东[1] 张洪美[1] 孙钢[1] 张磊[1] 顾力军[1] 赵铁军[1] 

机构地区：[1]中国中医研究院骨伤科研究所,北京100700 [2]中国中医研究院中药研究所

出　　处：《中国骨伤》2003年第2期69-70,共2页China Journal of Orthopaedics and Traumatology

摘　　要：目的　研究非创伤性股骨头坏死与血浆脂质变化的相关性。方法　研究对象 12 0例 ,其中 60例非创伤性股骨头坏死患者和 60例正常人 ,采用奥林帕斯 (Olypas)AU 40 0全自动生化分析仪 ,检测总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)等指标。结果　股骨头坏死组与正常对照组血浆脂质及载脂蛋水平比较 ,TC、TG、LDL、ApoB明显升高 (P <0 0 5 ) ,HDL、ApoAI明显降低 (P <0 0 5 ) ,ApoB/ApoAI比值显著升高 (P <0 0 0 1)。结论　非创伤性股骨头坏死的发生和发展与血浆中的脂蛋白有密切关系 。Objective To study the relationship between non-traumatic necrosis of the femoral head and blood plasma lipid Methods 60 patients and 60 normal people were included in the study.Total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),apolipoprotein AI(ApoAI)and apolipoprotein B(ApoB) were determined with the automatism biochemical analysor of Olypas AU 400.Results Comparison between the patients and the normal controls showed that TC,TG,LDL and ApoB were significantly higher,(P<0.05),HDL and ApoAI were significantly lower in the patients than that in the normal control(P<0.05).ApoB/ApoAI ratio was also significantly higher in the patients than that in the normal control (P<0.001).Conclusion There was a significant association between change of lipoprotein and development of non-traumatic necrosis of the femoral head.A high ApoB/ApoAI ratio has clinical significance to estimate developing of non-traumatic osteonecrosis.

关 键 词：非创伤性股骨头坏死 血浆 脂蛋白 相关性 载脂蛋白B 载脂蛋白AI 检测 

分 类 号：R681.8[医药卫生—骨科学] R446.11[医药卫生—外科学]