镍超氧化物歧化酶模拟化合物的合成、表征及活性  

Synthesis, Characterization and Biological Activity of Simulated Compounds with Nickel-containing Superoxide Dismutase Mimics

作　　者：刘媛媛[1] 岳俊杰[1] 刘小兰[1] 

机构地区：[1]天津师范大学化学与生命科学学院,天津300074

出　　处：《天津师范大学学报（自然科学版）》2003年第2期1-3,共3页Journal of Tianjin Normal University：Natural Science Edition

基　　金：天津市教委重点学科资助项目(990712)

摘　　要：合成了3种具有苯并咪唑基的配体(N3,NTB,EDTB)及其与金属镍的配合物,由此模拟镍超氧化物歧化酶(Ni-SOD)的活性中心结构,对所合成的模拟化合物进行了元素分析和红外、紫外光谱的结构表征,并利用改进的邻苯三酚自氧化法测定了模拟化合物的生物活性.In order to simulate the active site of nickelcontaining superoxide dismutase, three benzimidazolcontaining ligands N,Nbis(benzimidazol2ylmethyl) amine(N3),N,N,Ntri(benzimidazol2ylmethyl) amine(NTB), N,N,N`,N`tetrakis(benzimidazol2ylmethyl)1,2ethanediamine(EDTB) and their complexes with nickel ion were synthesized. The complexes were characterized by elemental analysis, IR and UV spectrums, and their biological activities were determined by means of improved pyrogallol autoxidation.

关 键 词：镍超氧化物歧化酶 模拟化合物 合成 结构表征 生物活性 镍配合物 活性中心结构 

分 类 号：O614.813[理学—无机化学] O629.8[理学—化学]