冠心病房颤患者不同伴发病变血清脂蛋白(a)的改变  

The changes of serum lipoprotein(a) in coronary heart disease patients with atrial fibrillation complicated with associated diseases

作　　者：梁创[1] 陈洁清[2] 陈灿[2] 吴小玲[2] 麦航[2] 

机构地区：[1]广东省遂溪县人民医院,524300 [2]广东医学院附属医院,广东湛江524001

出　　处：《中国综合临床》2003年第7期596-597,共2页Clinical Medicine of China

摘　　要：目的观察冠心病房颤患者不同伴发病变血清脂蛋白 (a) [Lp(a) ]的变化。 方法采用ELISA法检测冠心病患者(44例 ,Ⅰ组 )、冠心病房颤伴发糖尿病 (40例 ,Ⅱ组 )或伴发高血压病 (41例 ,Ⅲ组 )或伴发慢性支气管炎 (慢支 )患者 (37例 ,Ⅳ组 )血清Lp(a)。 结果冠心病房颤伴糖尿病组血清Lp(a)水平显著高于冠心病组、冠心病房颤其他各组及正常对照组 (P <0 .0 1) ;冠心病组、冠心病房颤各组血清Lp(a)水平均显著高于正常对照组 (P <0 .0 1) ,而冠心病组及冠心病房颤伴发高血压病或伴慢支 3组患者血清Lp(a)水平无差异 (P >0 .0 5 )。 结论血清Lp(a)的增高可能是导致冠心病房颤血栓形成及脑梗死等并发症发生的原因之一 ,在冠心病房颤常见伴发病中 ,尤应注意伴发糖尿病时Lp(a)的变化。Objective To observe the changes of serum lipoprotein(a)[Lp(a)]in coronary heart disease patients with atrial fibrillation(AF) complicated with various kinds of associated disease. Methods The serum Lp(a) levels were determined by ELISA in simple coronary heart disease patients(I group,n=44), coronary heart disease patients with AF complicated with associated diabetes(II group, n=40), in coronary heart disease patients with AF complicated with associated hypertension(group III, n=41) and in coronary heart disease patients with AF complicated with chronic bronchitis(group IV, n=37). Results Lp(a) was obviously higher in II group than that in I, III, IV group(P<0.01), while the Lp(a) level in each group was remarkably higher than that in control group(P<0.01).However, there was no difference in Lp(a) level between I group and III group or IV group (P<0.05). Conclusion The increased level of Lp(a) can be one of the reasons resulting in AF thrombosis and cerebral infarct. Special attention should be paid to the changes of Lp(a) when the patients are complicated with diabetes among the associated diseases of CHD AF.

关 键 词：冠状动脉疾病 心律失常 脂蛋白(a) 

分 类 号：R541.4[医药卫生—心血管疾病]