旋毛虫感染母鼠产小鼠抗血吸虫感染保护性的初步研究  

PROTECTIVE EFFECTS OF OFFSPRING OF MOTHER-MICE INFECTED WITH TRICHINELLA SPIRALIS AGAINST SCHISTOSOMA JAPONICUM INFECTIONS

作　　者：彭飞[1] 黄琼瑶[1] 刘年猛[1] 冯芳[1] 胡琦[1] 

机构地区：[1]湖南师范大学医学院,长沙410006

出　　处：《中国血吸虫病防治杂志》2003年第3期182-184,共3页Chinese Journal of Schistosomiasis Control

基　　金：湖南省卫生厅 ( 0 0 0 79);湖南省教育厅资助项目( 0 0 C0 0 6)

摘　　要：目的　探讨旋毛虫感染母鼠产小鼠抗血吸虫感染的保护性效果。方法　用旋毛虫感染母鼠产子代小鼠及该小鼠血清经尾静脉和肌肉注射被动转移小白鼠 ,在感染血吸虫尾蚴 42 d后解剖检虫 ,检测小鼠对血吸虫感染的保护效果。结果　旋毛虫感染母鼠产小鼠减虫率为 2 4.3 1% ,其小鼠血清静脉和肌肉注射被动转移小白鼠减虫率分别为 18.65 %和 2 0 .77%。Objective To explore the acquired immunity against Schistosoma japonicum infections in the offspring of mother-mice infected with Trichinella spiralis.Methods The offspring of mother-mice infected with Trichinella spiralis and the mice after passively transferring the offspring's sera were sacrificed at day 42 post infection with S. japonicum cercariae. The percentage of reduction in worm burdens was calculated to determine the protective effects. Results Comparing with the control group, the reduction rates of the worm were 24.31% in the offspring, 18.65% and 20.77% in mice with passively transferring the offspring's sera by intravenous injection and muscular injection respectively. Conclusion The offspring of mother-mice infected with Trichinella spiralis and the mice with passively transferring the offspring's sera could acquire protective immunity against Schistosoma japonicum infections.

关 键 词：旋毛虫 子代 被动转移 日本血吸虫 尾蚴 保护性免疫 

分 类 号：R383.24[医药卫生—医学寄生虫学]