高甘油三酯血症对血管内皮功能的影响  

The effects of hypertriglyceridemia on vascular endothelial function

作　　者：黄芸[1] 戴闺柱[1] 冯宗忱[2] 鲁成发[3] 成蓓[1] 王秋芬[1] 聂福鼎[1] 李景东[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心内科 [2]华中科技大学同济医学院生化教研室 [3]华中科技大学同济医学院附属协和医院超声科

出　　处：《中华心血管病杂志》2003年第6期421-423,共3页Chinese Journal of Cardiology

摘　　要：目的　观察高甘油三酯血症对血管内皮功能的影响。方法　对 30名高甘油三酯血症患者和 30名正常人采用高分辨超声技术检测血流介导和硝酸甘油介导的肱动脉舒张功能 ,并测定血浆内皮素和血脂。结果　 (1)高甘油三酯血症患者血流介导的肱动脉舒张较正常组明显减弱 [分别为(2 7± 2 0 ) %和 (15 0± 8 0 ) % ,P <0 0 0 1],而两组对硝酸甘油的血管舒张反应无显著性差异 [分别为 (15 0± 5 0 ) %和 (16 8± 9 0 ) % ,P >0 0 5 ]。 (2 )高甘油三酯血症患者血浆内皮素水平 [(10 6 2 2± 19 16 ) μg/L]显著高于正常组 [(72 37± 14 0 6 ) μg/L](P <0 0 0 1)。 结论　高甘油三酯血症患者内皮依赖性血管舒张功能明显受损。血管内皮功能失调可能是高甘油三酯血症致动脉粥样硬化的一个重要机制。Objective To investigate the effects of hypertriglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow- and nitroglycerin-induced dilation of the brachial artery was measured in 30 hypertriglyceridemic patients and 30 healthy subjects (control group). Both serum lipid and plasma endothelin (ET) levels were determined at the same time. Results (1) In patients with hypertriglyceridemia, flow-induced vasodilatation was much reduced compared with that in the control subjects [(2.7 ±2.0)% vs (15.0±8.0)%, P <0.001]. However, vasodilatation in response to nitroglycerin was similar in both groups [(15.0±5.0)% vs (16.8±9.0)%, P >0.05]. (2) Plasma ET level in the hypertriglyceridemic group [(106.22±19.16)μg/L] was significantly higher than that in the control group [(72.37±14.06)μg/L]( P <0.001).Conclusions Endothelium-dependent vasodilatation is impaired in patients with hypertriglyceridemia. The endothelial dysfunction may contribute to the atherogenic actions of hypertriglyceridemia.

关 键 词：高甘油三酯血症 血管内皮功能 影响 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]