COPD合并肺部感染患者的细菌学特点及药物敏感性分析  

Characteristics of bacteriology and drug sensitivity in patients with COPD combined with pneumonia

作　　者：易智明[1] 杨华 向旭东[1] 

机构地区：[1]中南大学湘雅二院呼吸内科,长沙410011 [2]龙山县人民医院内科,龙山416800

出　　处：《湖南医科大学学报》2003年第3期272-274,共3页Bulletin of Hunan Medical University

摘　　要：目的 :为了解我院近一年来呼吸重症监护病房 (RICU)慢性阻塞性肺疾病 (COPD)合并肺部感染患者中细菌学特点及耐药性变化规律。方法 :按常规方法收取 5 34例COPD合并肺部感染患者的痰液 ,采用K B药敏纸片法进行细菌培养及药物敏感性分析。结果 :5 34例中有 1 81例培养阳性 ,阳性率为 33.9%。主要病原菌G 为铜绿假单胞菌 (2 1 .5 5 % )、流感嗜血杆菌 (1 4 .36 % )、肠杆菌属 (1 3.2 6 % )、肺炎克雷伯杆菌 (1 1 .6 0 % ) ,对亚胺培南 /西司他丁、丁胺卡那霉素及头孢他啶敏感 ;G+ 菌为金黄色葡萄球菌 (7.1 8% )和表皮葡萄球菌 (4 .4 2 % ) ,对万古霉素、亚胺培南 /西司他丁、头孢他啶及丁胺卡那霉素等敏感。结论 :我院近一年来RICU中COPD合并肺部感染患者的细菌学特点为以G 为主 ,G+ 球菌次之 ,他们均对亚胺培南 /西司他丁、头孢他啶及丁胺卡那霉素敏感 ,而G+Objective To investigate the characteristics of bacteriology and the drug resistance in the patients with chronic obstructive pulmonary disease(COPD) combined with pneumonia at our respiratory intensive care unit(RICU) in 2001.Methods The sputum of 543 patients with COPD combined with pneumonia was collected with a regular method,the bacteria were cultured,and then the drug sensitivity was analyzed with K B method.Results There were 181 positive samples in the 543 patients with the positive rate 33.9%.The main bacteria in the G bacillus were Pseudomonas (21.55%), Haemophilus influenza (14.36%),Enteric bacilli (13.26%),and Klebsiella (11.60%) which were sensitive to imipenem, amikacin, and ceftazidime.The main bacteria in G + bacteria were Staphyloccus aureus (7.18%) and Staphyloccus epidermindis (4.42%) which were sensitive to vancomycin, imipenem,ceftazidime,and amikacin.Conclusion The bacteria in the patients with COPD combined with pneumonia at RICU of the hospital in 2001 are mainly made up of G bacillus and secondarily of G + bacteria which are sensitive to imipenem,amikacin,and ceftazidime. The G + bacteria are highly sensitive to vancomycin.

关 键 词：COPD 肺部感染 细菌学特点 药物敏感性 

分 类 号：R446.5[医药卫生—诊断学]