化学发光免疫法与免疫放射法检测血清TSH的临床价值比较  

Clinical value comparison between chemiluminescent immunoassay and immunoradiometric assay in detecting TSH in serum

作　　者：余剑英[1] 林英[1] 

机构地区：[1]中南大学湘雅医院核医学科,长沙410008

出　　处：《湖南医科大学学报》2003年第3期275-277,共3页Bulletin of Hunan Medical University

摘　　要：目的 :比较化学发光免疫分析 (CLIA)及免疫放射分析 (IRMA)检测血清促甲状腺激素 (TSH)对诊断甲状腺机能亢进 (甲亢 )及甲状腺机能减低 (甲减 )的临床价值。方法 :用CLIA与IRMA对 1 1 2例正常人、1 2 0例甲亢病人、5 8例甲减病人血清标本TSH含量进行测定。结果 :两法的相关性良好 (r=0 .98,P <0 .0 1 ) ,但CLIA对甲亢及甲减的诊断临床符合率比IRMA高 ,且CLIA的精密度 (批内变异 )和重复性 (批间变异 )均优于IRMA。结论 :CLIA对甲亢及甲减的诊断优于IRMA。Objective To compare the clinical value between chemiluminescent immunoassay (CLIA) and immunoradiometric assay (IRMA) in detecting TSH in patients with hyperthyroidism and hypothyroidism.Methods The TSH levels in serums were detected by CLIA and IRMA in 112 normal persons,120 hyperthyroidism patients and 58 hypothyroidism patients.Results CLIA was significantly correlated with IRMA ( r=0.98,P <0.01). CLIA had higher coincidence rate than IRMA in the diagnosis of hyperthyroidism and hypothyroidism,and CLIA was more accurate and repetitive than IRMA. Conclusion CLIA is more valuable than IRMA in diagnosing both hyperthyroidism and hypothyroidism .

关 键 词：化学发光免疫法 免疫放射法 检测 血清 TSH 甲状腺机能亢进 甲状腺机能减低 

分 类 号：R446.6[医药卫生—诊断学] R817.4[医药卫生—临床医学]