血清胆固醇酯转运蛋白的变化及临床应用  

Change of Serum Cholesteryl Ester Transfer Protein and Its Clinical Application

作　　者：李小明[1] 贺小玲[2] 胡汉宁[2] 

机构地区：[1]武汉大学医学院生物化学与分子生物学系,武汉430071 [2]武汉大学中南医院检验科,武汉430071

出　　处：《武汉大学学报（医学版）》2003年第3期274-276,共3页Medical Journal of Wuhan University

摘　　要：目的 :了解胆固醇酯转运蛋白 (CETP)对动脉粥样硬化的致病关联性。方法 :以ELISA法检测正常健康者及患者血清中CETP的浓度 ,同时检测了血脂其他相关指标。进行统计学处理 ,进行正态性检验 ,相关性分析 ,参考值的确定。结果 :正态性检验呈正偏态分布。参考范围 0 .33～ 4 .7mg·L- 1 。CETP与脂类其它指标无明显的相关性。结论 :显示CETP浓度过高或过低或缺乏均与动脉粥样硬化的形成存在着明显的关联性 ,具有临床应用价值。Objective: To study the relation between serum cholesteryl ester transfer protein(CETP) concentration and atherosclerosis(AS) pathogenesis.Methods: Serum CETP concentration and other blood lipid correlated indexes were measured,by ELISA method. Statistical analysis such as normality test,correlation analysis and determination of reference value were done. Results: The normality test showed positive partial distribution,the reference interval was 0.33～4.7 mg·L -1 . There was no significant correlation between serum CETP concentration and other blood lipid indexes. Conclusion: There is a significant correlation between the formation of atherosclerosis plaques and the abnormal changes of serum CETP concentration.

关 键 词：血清 胆固醇酯转运蛋白 临床应用 动脉粥样硬化 统计学处理 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]