心力衰竭患者血浆白细胞介素18的检测及临床意义  

Detection of plasma interleukin 18 in patients with congestive heart failure and its clinical significance

作　　者：许金成[1] 王淑斐[1] 刘华锋[2] 袁岩[3] 洪玉芬[3] 

机构地区：[1]深圳市宝安人民医院心内科,广东深圳518101 [2]广东医学院附属医院肾脏病研究所,广东湛江524001 [3]广东医学院附属医院心内科

出　　处：《中国急救医学》2003年第7期442-443,共2页Chinese Journal of Critical Care Medicine

基　　金：广东省卫生厅科研基金立项课题 (A2 0 0 14 88)

摘　　要：目的　探讨充血性心力衰竭 (CHF)患者血浆白细胞介素 18(IL - 18)水平的变化及临床意义。方法　采用ELISA法检测 4 8例CHF患者血浆IL - 18水平 ,以 30例健康者做比较 ,分析CHF患者治疗前后血浆IL - 18水平的变化及不同心功能的CHF患者血浆IL - 18水平的变化。结果　CHF患者血浆IL - 18水平显著高于正常对照组 (t =4 .4 5 0 ,P <0 .0 1) ,治疗后显效者血浆IL - 18水平显著下降 (t =9.384 ,P <0 .0 0 1) ,不同心功能的CHF患者血浆IL - 18水平差异显著 (F =2 5 0 .75 9,P <0 .0 1) ,随心功能恶化而升高 (P <0 .0 2～ 0 .0 0 1)。结论　IL - 18可能参与CHF的发生及发展过程。Objective To study the changes of the levels of plasma interleukin-18(IL-18) in the patients with congestive heart failure(CHF) and its clinical significance. Methods The levels of plasma IL-18 in 48 patients with CHF were measured by enzyme linked immune sandwich assay(ELISA), 30 healthy person(HP) as control group. The changes of the levels of plasma IL-18 in patients with CHF before and after treatment, and the relationship of the levels of plasm IL-18 in the patients with different degree of CHF were analysed. Result The results showed that the levels of plasma IL-18 in patients with CHF were significantly higher than the HP(t=4.450,P< 0.01 ).The levels of plasma IL-18 in the effective patients with CHF after treatment were lower than that before treatment(t=9.384, P< 0.001 ), and progressively elevated with the worsening of the heart dysfunction(P<0.02～0.001).Conclusion IL-18 might participate the pathogenesis and progress of CHF.

关 键 词：充血性 心力衰竭 白细胞介素18 

分 类 号：R541.6[医药卫生—心血管疾病]