美心力 心先安对左室做功和机械效率的影响  

Effects of cAMP and M-cAMP on left ventricular work efficiency:assessment by left ventricular pressure-volume analysis

作　　者：李悦[1] 迟静茹[2] 李为民[1] 韩薇[1] 杨树森[1] 王凤龙 刘丕栋[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院心血管内科,黑龙江哈尔滨150001 [2]哈尔滨市第一医院老年病科 [3]大庆市第五医院心血管内科

出　　处：《中国急救医学》2003年第7期447-448,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　评价美心力 (cAMP)、心先安 (葡甲胺 -cAMP)对左室做功和机械效率的影响。方法　建立心内置入压力、容积测定装置的犬模型 ,利用压力 -容积关系分析美心力和心先安对左室做功和机械效率的影响。结果　阻滞自主神经前 ,美心力和心先安都能够改善左室与动脉系统的协调耦联 ,使EES/Ea值增加 (0 4 8± 0 .0 5vs 0 .6 8± 0 .0 6 ,P <0 0 5 ;0 5 0±0 0 6vs 0 .6 7± 0 .0 6 ,P <0 0 5 ) ;能够增强左室机械效率 ,使SW/PVA值增大 (0 4 8± 0 0 5vs 0 .5 7± 0 .0 6 ,P <0 0 5 ;0 5 0± 0 0 4vs0 .5 9± 0 .0 6 ,P <0 0 5 ) ;且不增加心脏做功。阻滞自主神经后 ,这些作用仍然存在。结论　美心力和心先安能够改善左室与动脉系统的耦联 ,提高左室机械效率 ,降低心肌氧耗。Objective To investigate the effects of cAMP and M-cAMP on left ventricular (LV) work efficiency. Methods We assessed the effects of cAMP (10 mg/kg) and M-cAMP (10 mg/kg) on LV work efficiency in 8 anesthetized dogs before and after autonomic blockade. Variably loaded pressure-volume loops were generated by transient caval occlusion. Results With reflexes intact, both cAMP and M-cAMP increased the E_ ES /Ea ratio (0.48±0.05 vs 0.68±0.06, P<0.05;0.50±0.06 vs 0.67±0.06,P<0.05) and the SW/PVA ratio(0.48±0.05 vs 0.57±0.06, P<0.05;0.50±0.04 vs 0.59±0.06,P<0.05). These effects preserved after autonomic blockade. Conclusion Both cAMP and M-cAMP could improve LV work efficiency and decrease oxygen consumption.

关 键 词：环磷酸腺苷 犬 压力-容积关系 左心室功能 

分 类 号：R965[医药卫生—药理学]