硬膜外病人自控镇痛对血浆内皮素的影响  

The Effect of Postoperative Controlled Eoidural Analgesia on Serum Endothelin

作　　者：李景锋[1] 郭富祥[1] 刘兵[1] 

机构地区：[1]解放军第205医院麻醉科,辽宁锦州121001

出　　处：《锦州医学院学报》2003年第3期46-47,共2页Journal of Jinzhou Medical College

摘　　要：目的　了解硬膜外病人自控镇痛 (PCEA)对血浆内皮素 (ET)的影响。方法　选择 4 0例下肢电击伤病人 ,均在硬膜外麻醉下行皮瓣修复术 ,随机分为PCEA组 (P组 )及非PCEA组 (N组 ) ,每组 2 0人。P组病人用硬膜外病人自控镇痛 ,N组病人术后根据需要间断肌注度冷丁。分别在麻醉前、术后 12h、 2 4h、 4 8h静脉采血测血浆内皮素浓度 ,观察两组病人血浆内皮素浓度的变化。结果　PCEA组术后血浆内皮素浓度下降明显。结论　PCEA能有效消除术后病人因伤口疼痛引起的焦虑及交感神经兴奋引起的血管收缩 ,从而加速皮瓣的动脉血供及静脉回流 。Objective The purpose of this study was to investigate the effect of postoperative patient controlled with epidural analgesia(PCEA)on serum endothelin(ET).Methods Forty patients with electric burn on lower limb undergoing flap repair were studied.Flap repair were performed under epidural anesthesia.The patients were divided into 2 groups of 20 each.PCEA group(P)and non-PCEA group(N).In group P patients received PCEA,In group N,patients received intromuscular dolantin on demand.Blood samples were taken before anesthesia and 12h,24h,48h after operation for determination of serum endothelin.Results In group P,the serum endothelin dropped rapidly after operation.Conclusions PCEA can relieve pain and anxeity induced by stimulation of sympathetic activity and improve flap function in patients after flap repair.

关 键 词：硬膜外病人自控镇痛 血浆 内皮素 下肢电击伤 皮瓣修复术 

分 类 号：R647[医药卫生—外科学] R614.42[医药卫生—临床医学]